این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Pathology، جلد ۱۶، شماره ۱، صفحات ۶۲-۶۸
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Variants of Genes Involved in Metabolism of Folate among Patients with Breast Cancer: Association of TYMS 3R Allele with Susceptibility to Breast Cancer and Metastasis
چکیده انگلیسی مقاله Background & Objective: Breast cancer (BC) is known to be the most prevalent cancer among women. One-carbon metabolism (OCM) disturbance might play an important role in the etiology of BC. The present study aimed to investigate the thymidylate synthase (TYMS), 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR), and methionine synthase reductase (MTRR) variants as good candidates for studying the role of genetic variants of folate metabolizing enzymes in the risk of BC.
Methods: The present case-control study consisted of 100 BC patients and 141 healthy females. The TYMS 2R/3R (rs34743033), MTR c.2756A>G (rs1805087), and MTRR c.66A>G (rs1801394) variants were detected by polymerase chain reaction (PCR), PCR-restriction fragment length polymorphism (RFLP), and a designed amplification-refractory mutation system (ARMS) method, respectively.
Results: The 3R allele of TYMS enhanced the risk of BC by 2.84-fold (p <0.001). In the presence of TYMS 3R/3R, compared to TYMS 2R/3R, there was a trend toward enhancing the risk of metastasis by 4.15-fold (95% CI: 0.96-17.85, p =0.055). The frequencies of MTR c.2756A>G and MTRR c.66A>G variants were not significantly different among patients and controls.
Conclusion: We observed that the TYMS 3R is a risk allele for susceptibility to BC and this allele tends to increase the BC metastasis.
کلیدواژه‌های انگلیسی مقاله Breast cancer,Thymidylate synthase,Methionine synthase,Methionine synthase reductase,Polymorphism,Metastasis
نویسندگان مقاله Zohreh Rahimi |
Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

Maryam Bozorgi Zarini Bozorgi Zarini |
Department of Clinical Biochemistry, Kermanshah University of Medical Sciences

Ziba Rahimi |
Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

Ebrahim Shakiba |
Department of Clinical Biochemistry, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran

Asad Vaisi-Raygani |
Fertility and Infertility Research Center, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran

Mohammad Taher Moradi |
Medical Biology Research Center, Kermanshah University of Medical Sciences

Kheirolah Yari |
Medical Biology Research Center, Kermanshah University of Medical Sciences

نشانی اینترنتی https://ijp.iranpath.org/article_46863_ada2366d6e4658b67e4b78b93513586b.pdf
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات