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Iranian Journal of Pathology، جلد ۱۶، شماره ۱، صفحات ۹۰-۹۴
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عنوان انگلیسی Postoperative Extra-Cranial Metastasis of Glioblastoma: A Case Report
چکیده انگلیسی مقاله Glioblastoma (WHO grade IV) is the most common malignant tumor of neural tissues in adults as a primary tumor. Because of blood brain barrier and short median survival of patients with glioblastoma, metastasis of this tumor is very rare. A 46-year-old man was admitted to Sina hospital with chief complaint of headache and visual impairment. After neuro-radiologic evaluation the patient underwent surgery. Pathologic examination of the tumor confirmed the diagnosis of glioblastoma multiforme. Cytogenetic study of the tumor cells confirmed GBM IDH1 wild type with TERT mutation and EGFR amplification. Two months after surgical resection, the tumor recurred with involvement of the dura matter. After the second operation, metastasis to the pelvic cavity and cervical lymph node was found. Almost all cases of glioblastoma metastasis had undergone surgery or any manipulation; this fact suggests that iatrogenic intra-vascular seeding of tumor cells at the time of resection and disruption of blood brain barrier could cause extra-neural metastasis.
کلیدواژه‌های انگلیسی مقاله Brain tumor,Glioblastoma,Metastasis,Pelvic Cavity
نویسندگان مقاله Atieh Zandnejadi |
Department of Pathology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Arezoo Eftekhar-Javadi |
Department of Pathology, Sina hospital, Tehran University of Medical Sciences, Tehran, Iran

HEDIEH MORADI TABRIZ |
Tehran University of Medical Sciences

نشانی اینترنتی https://ijp.iranpath.org/article_46933_946e10e9aed4f6e1e17665d11c2b4619.pdf
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