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Iranian Journal of Pathology، جلد ۱۵، شماره ۴، صفحات ۲۶۸-۲۷۳
عنوان فارسی
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عنوان انگلیسی Assessment of p16 and Ki67 Immunohistochemistry Expression in Squamous Intraepithelial Lesion with Cytohistomorphological Correlation
چکیده انگلیسی مقاله Background & Objective:
Cervical cancer is the most common cancer in women worldwide with high mortality, necessitating quicker diagnostic methods. We wish to enhance the existing cervical biopsies of Squamous Intraepithelial Lesions (SIL) using p16 and Ki67 as surrogate markers to assess correlation between its positivity and histological grade of the lesion.
Methods:
Analysis of p16 and Ki67 expression was done on 31 histopathologically diagnosed cases of SILs. Positive expression of p16 was assessed based on a scoring system and compared with histology and cytology. Ki67 expression was studied and the correlation was observed with degree of dysplasia. Twenty cases of chronic cervicitis was assigned to the control group for comparison.
Result:
Cases of HSIL showed greater expression of p16 as compared to LSIL. Sensitivity of p16 for HSIL was higher than that for LSIL. The specificity for HSIL and LSIL was 100%. Ki67 expression correlated well with the degree and level of dysplasia with a significant P-value of 0.002.
Conclusion:
p16 and Ki67 positivity of SILs should point towards further evaluation. The expressions of p16 and Ki67 are useful markers for confirmation of SILs and in predicting HPV infection which can be further confirmed by HPV DNA testing.
کلیدواژه‌های انگلیسی مقاله Squamous intraepithelial lesion,HSIL,LSIL
نویسندگان مقاله Apurv Ghosh |
Department of Pathology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, India

M Nirupama |
Department of Pathology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, India

Nandan Padmanabha |
Department of Pathology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, India

Hema Kini |
Department of Pathology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, India

نشانی اینترنتی https://ijp.iranpath.org/article_43484_c582b5579250228a546c0506f10592b0.pdf
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