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Iranian Journal of Pathology، جلد ۱۵، شماره ۴، صفحات ۲۷۴-۲۸۱
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Investigation of HER-2 expression and its Correlation with clinicopathological parameters and overall survival of esophageal squamous cell carcinoma patients
چکیده انگلیسی مقاله Background & Objective:
Human epidermal growth factor receptor 2 (HER-2) exhibits a vast range of expression in esophageal squamous cell carcinoma (ESCC) patients as a biomarker. This paper aimed to investigate HER-2 expression and clinicopathological parameters of esophageal SCC.
Methods:
HER-2 expression was assessed in 102 ESCC patients by immunohistochemistry. The HER-2 staining intensity , according to the Gastric HER2 Biomarker1.0.0.1 version of the college of American pathologists (CAP) protocol for gastric and gastroesophageal junction cancers, was graded as 0 (no reactivity in any of the cancer cells’ membranes); 1+ (pale or hardly noticeable reactivity in the membrane of cancer cells’ cluster [≥ 5 neoplastic cells] regardless of the positive cancer cells’ percentage); 2+ (weak-to-moderate complete, basolateral, or lateral membranous reactivity regardless of the positive cancer cells’ percentage); and 3+ ( strong complete, basolateral, or lateral reactivity in the membrane of the cancer cell cluster regardless of the positive cancer cells’ percentage).In this regard, 3+ scored samples were considered as positive. If HER-2 expression was scored 2+, an additional fluorescence in situ hybridization (FISH) was performed. Fisher's exact test was employed for investigating the correlation of HER-2 expression status with patients’ clinicopathological characteristics (including age, gender, tumor location, stage, grade, infiltration level, venous invasion, lymphatic invasion, and tumor recurrence). Kaplan-Meier analysis was done for the patients’ survival assessments.
Result:
Five patients (~5%) were HER-2 positive and no significant association was observed between HER-2 expression and clinicopathological properties. In addition, HER-2 expression status exhibited no significant association with the patients’ overall survival (p =0.9299). 
Conclusion:
HER-2 is not a suitable prognostic biomarker for Iranian ESCC patients.
کلیدواژه‌های انگلیسی مقاله HER-2 receptor,Esophageal cancer,Squamous cell carcinoma
نویسندگان مقاله Mitra Heidarpour |
Department of Pathology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Mehran Taheri |
Department of Pathology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Ali Akhavan |
Department of Radiation Oncology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Parvin Goli |
Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Amirhosein Kefayat |
Department of Oncology, Cancer Prevention Research Center, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

نشانی اینترنتی https://ijp.iranpath.org/article_43485_75bef0daae6230c679a7180cc7eb0e46.pdf
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