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Research Journal of Pharmacognosy، جلد ۱۰، شماره ۲، صفحات ۴۷-۵۶
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چکیده فارسی مقاله
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عنوان انگلیسی Bacteriostatic and Haemolytic Activities of Extracts and Compounds of Commiphora swynnertonii
چکیده انگلیسی مقاله Erratum notice

This is to correct some information published in the article: ”Bacteriostatic and Haemolytic Activities of Extracts and Compounds of Commiphora swynnertonii” in 10(2) issue of Research Journal of Pharmacognosy. The corresponding author has contacted the journal editorial office and asked for correction of some parts of the article. Based on his explanations, the article has been corrected and replaced. Corrected parts are listed below:

Pages 47 and 48: The scientific name of the plant was corrected to: Commiphora swynnertonii (Burtt).
Page 52: “Extracts from whole root and leaves at the concentration …” was corrected to: “Extracts from root bark and leaves at the concentration...”.
Page 52: Figure 2 caption was corrected to D) leaves
Page 54: “Test for haemolytic activity showed that extracts of whole root, root bark and root wood ...” was corrected to: Test for haemolytic activity showed that extracts of whole root and root wood …”
Page 54: “The study noted that the use of whole root and leave…” was corrected to: “The study noted that the use of root bark and leave…”
Page 54: “Apart from cytotoxicity in red blood cells, the cytotoxicity test in brine shrimp found that extracts from the leaves of swynnertonii were highly toxic and extracts from the root bark were less toxic.” was corrected to: “Apart from cytotoxicity in red blood cells, the cytotoxicity test in brine shrimp found that extracts from the leaves of C. swynnertonii were highly toxic.”

 
Background and objective: Commiphoraswynnertonii (Pax) is used in traditional medicine to treat infectious diseases. Previous studies have reported antimicrobial activity of this plant;however, the activity of compounds that are present in extracts of this plant has not been thoroughly documented. Likewise, the primary mode of action (bactericidal or bacteriostatic) and the possible toxicity on red blood cells have not been reported. Methods: Extracts of leaves, whole root, root bark, root wood, whole stem, stem bark and stem wood, were produced using hexane, dichloromethane, methanol and water. Cold and hot extraction methods were employed. Antibacterial activity of extracts was tested against selected medically important Gram-positive and Gram-negative bacteria by growth inhibition, minimum inhibitory concentrations and time kill assays. Moreover, haemolytic activity against sheep red blood cells was determined in vitro. Results: The hexane extracts of whole root and root bark, methanol extracts of root wood, and dichloromethane extracts from the leaves of C. swynnertonii inhibited the growth of S. aureus. MIC values for the extracts and compounds, indicated moderate activity against Gram-positive bacteria (Staphylococcus aureus, Streptococci species and Enterococci species) while the activity against Gram-negative bacteria (Escherichia coli, Klebsiella species, Pseudomonas aeruginosa, Salmonella species, Shigella sonnei and Yersinia enterocolitica) was weak. Time kill profiles showed the extracts have bacteriostatic activity against S. aureus, and low haemolytic effect, except for extracts of whole root and leaves at the concentration of 1000 µg/mL. Conclusion:Extracts of C. swynnertonii showed bacteriostatic activity against Gram-positive bacteria with low toxicity on red blood cells.
 
کلیدواژه‌های انگلیسی مقاله antibacterial,Commiphora swynnertonii,Medicinal plant,Red blood cells
نویسندگان مقاله Zaituni Msengwa |
Department of Chemistry and Physics, Sokoine University of Agriculture, Morogoro, Tanzania.

David Credo |
Department of Chemistry and Physics, Sokoine University of Agriculture, Morogoro, Tanzania.

Magesa Mafuru |
Department of Clinical Pharmacology and Therapeutics, Hubert Kairuki Memorial University, 322 Regent Estate, Dar es Salaam, Tanzania.

James Mwesongo |
Department of Biosciences, Sokoine University of Agriculture, Morogoro, Tanzania.

Faith Philemon Mabiki |
Department of Chemistry and Physics, Sokoine University of Agriculture, Morogoro, Tanzania.

Beda John Mwang’onde |
Department of Biosciences, Sokoine University of Agriculture, Morogoro, Tanzania.

Madundo Mkumbukwa Mtambo |
Tanzania Industrial Research and Development Organisation, Dar es Salaam, Tanzania.

Lughano Jeremy Kusiluka |
Department of Microbiology and Parasitology, School of Medicine and Dentistry, University of Dodoma, Dodoma, Tanzania.

Robinson Hammerthon Mdegela |
Department of Veterinary Medicine and Public Health, Sokoine University of Agriculture, Morogoro, Tanzania.

John Elmerdahl Olsen |
Department of Veterinary and Animal Sciences, University of Copenhagen, Stigbøjlen 4, Frederiksberg C, Denmark.

نشانی اینترنتی http://www.rjpharmacognosy.ir/article_168133_16a8d935967929c8949bdb8ca48263ba.pdf
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