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Research Journal of Pharmacognosy، جلد ۱۰، شماره ۱، صفحات ۲۳-۲۹
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عنوان انگلیسی Cancer Chemo-Preventive Effects of Red Propolis: a System Biology Approach
چکیده انگلیسی مقاله Background and objectives: Propolis is a natural product of honey bees that is characterized by therapeutic effects on diverse diseases. To elucidate the molecular mechanism of propolis effects on tumor, protein-protein interaction (PPI) network analysis of proteome data of Hep-2 cells treated with red propolis was conducted. Methods: Cytoscape V 3.9.1 and its plug-ins evaluated the differentially expressed proteins (DEPs) in terms of network construction and the corresponding topological features. Results: The results implied that six hub-bottlenecks including ACTB, GAPDH, HSP90AA1, HSPA8, HSP90AB1, and HSPA5 were present in the PPI network; however, only the last central protein was among DEPs. ClueGO+ CluePedia identified five related biological processes and three action types of their connections. Results refer to anticancer property of red propolis. Conclusion: The proposed crucial proteins and their linked biological processes may represent as key players in the anticancer underlying mechanism of red propolis.
کلیدواژه‌های انگلیسی مقاله Biological process,cancer,Network analysis,propolis,therapeutic
نویسندگان مقاله Reza Vafaee |
Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Mona Zamanian Azodi |
Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Mostafa Rezaei-Tavirani |
Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Zahra Razzaghi |
Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Babak Arjmand |
Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Somayeh Esmaeili |
Traditional Medicine and Materia Medica Research Center and Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran.

نشانی اینترنتی http://www.rjpharmacognosy.ir/article_161983_f51f623064d87e9d32cf6470902a548f.pdf
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