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Research Journal of Pharmacognosy، جلد ۹، شماره ۲، صفحات ۱-۷
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عنوان انگلیسی Design and Optimization of PLGA-Based Tribulus terrestris Loaded Nanoparticles
چکیده انگلیسی مقاله Background and Objectives: Novel drug delivery systems improve bioavailability of standardized plant extracts which enables them to cross the biological membranes. Biodegradable polymeric nanoparticle systems are an approach to circumvent problems in drug delivery. Tribulus terrestris growing in subtropical areas has exhibited some biological and pharmacological activities; it contains compounds like flavonoids and steroids. To improve bioavailability of active compounds of the plant, its extract was subjected to prepare nanoparticles. Methods: Aqueous ethanol 80% extract of the whole plant was used for preparation of encapsulated nanoparticles using poly DL-lactic-co-glycolic acid (PLGA) polymer. Mean particle size, polydispersity, drug loading and encapsulation efficiency of the nanoparticles systems were evaluated in various ratios of T. terrestris extract. Results: All the applied concentrations of the extract provided particles in nano-scale size (163-214 nm). By increasing the extract ratio encapsulation efficacy also increased ranging between 40.3-78.5%. Above 50% of the loaded extract released in the first 3 h and it continued for 10 days. Conclusion: the plant extract has been successfully encapsulated into PLGA polymer. The quantification of encapsulation efficiency and in vitro release also showed that application of the plant in pharmaceutical field can be improved using nanoparticles.
کلیدواژه‌های انگلیسی مقاله nano delivery system,Nanoparticle,plant extract,Polymers,Tribulus terrestris
نویسندگان مقاله Azadeh Manayi |
Medicinal Plants Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Nikoo Bagheri |
Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Rasoul Dinarvand |
Department of Pharmaceutics, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Mehdi Esfandyari-Manesh |
Nanotechnology Research Center, Tehran University of Medical Sciences, Tehran, Iran

Mahnaz Khanavi |
Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

نشانی اینترنتی http://www.rjpharmacognosy.ir/article_142096_ebfffb6540996383b6fab6efe1e7a86a.pdf
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