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Research Journal of Pharmacognosy، جلد ۹، شماره ۱، صفحات ۸۹-۱۰۱
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عنوان انگلیسی Efficacy of a Topical Herbal Cream Containing Frankincense Oil, Pumpkin Oil and Licorice Aqueous Extract in Patients with Mild-to-Moderate Plaque Psoriasis: a Randomized Clinical Trial
چکیده انگلیسی مقاله Background and objectives: Psoriasis is a prevalent, chronic, and inflammatory disorder with good response rates using novel treatment strategies. However, side effects are a limiting factor in long-time treatment. Recent studies have demonstrated that many natural remedies have fewer side effects, and are thus safer options. The aim of this study was to evaluate the efficacy of a novel topical herbal preparation in patients with plaque psoriasis. Methods: This randomized, triple-blind, vehicle-controlled, two-arm parallel trial was conducted in patients with mild-to-moderate plaque psoriasis (psoriasis area & severity index= PASI score< 12). We randomized 108 patients in 1:1 ratio to receive Boswellia-based cream (containing Boswellia spp. ethanolic extract, Boswellia spp. oil, Glycyrrhiza glabra extract, Cucurbita pepo pulp oil) or vehicle cream, both applied as a thin layer on skin lesions twice daily for four weeks. Results: Compared with vehicle, the Boswellia-based cream group showed greater reduction in mean PASI score from baseline to week two and from week two to week four (both p<0.001). After two weeks of therapy, Dermatology Life Quality Index decreased in both groups, but to a greater extent in the intervention group compared with vehicle (p=0.004). From week two to week four, this item showed an additional decrease in Boswellia-based group compared to vehicle (p=0.001). After four weeks of therapy, patients in the Boswellia-based group were more satisfied than patients in vehicle group (median score: 8 in Boswellia-based group and 5 in vehicle, p<0.001). Conclusions: The outcomes showed significant alleviation of psoriasis signs and symptoms with this herbal cream.
 
کلیدواژه‌های انگلیسی مقاله Clinical trial,medicinal plants,Persian medicine,Psoriasis,topical cream
نویسندگان مقاله Fatemeh Fadaei |
Department of Traditional Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Mohammad Hossein Ayati |
Department of Traditional Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Alireza Firooz |
Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran.

Shima Younespour |
Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

Morteza Abouali |
Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Science, Tehran, Iran.

Malihe Tabarrai |
Department of Traditional Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Laila Shirbeigi |
Department of Traditional Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran.

نشانی اینترنتی http://www.rjpharmacognosy.ir/article_140868_f0d38b893a1e09a3da9fa7aaa209b4d4.pdf
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