این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Research Journal of Pharmacognosy، جلد ۸، شماره ۲، صفحات ۶۳-۶۸
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی 50S Ribosomal Proteins Family is the Main Target of Cinnamon Extract: a Network Analysis
چکیده انگلیسی مقاله Background and objectives: It is reported that cinnamonconsumption is corelated with improving several diseases and advanced methods are applied to detect the molecular mechanism of this effect. The aim of this study was introducing the main protein targets of cinnamon extract. Methods: Among the 100 regulated significant differentially expressed proteins, the recognized individuals by STRING database plus 100 added first neighbors were included in a network and the central nodes of the network were determined and analyzed. Results: The queried and added proteins were included in a scale free network. Seven hub nodes as central proteins were determined as critical target proteins. Five hub proteins were members of 50S ribosomal proteins family and others weretsf and dnaK. The last two hubs were related to protein synthesis and protein folding processes, respectively. Conclusion: 50S ribosomal proteins family and protein synthesis were identified as the main target of cinnamon and the core affected process, respectively.
کلیدواژه‌های انگلیسی مقاله Bioinformatics,Cinnamon,hub protein,Network analysis,proteomics
نویسندگان مقاله Mostafa Rezaei Tavirani |
Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Mahmood Khodadoost |
Department of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Babak Arjmand |
Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Mohamadreza Razzaghi |
Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Alireza Ahmadzadeh |
Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

نشانی اینترنتی http://www.rjpharmacognosy.ir/article_125670_22caf7b63fab80489ea68a88735f3a41.pdf
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات