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Research Journal of Pharmacognosy، جلد ۷، شماره ۴، صفحات ۳۹-۴۷
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عنوان انگلیسی Formulation and Finger Printing of a Poly Herbal Film-Coated Tablet for Treatment of Hemorrhoids
چکیده انگلیسی مقاله Background and objectives: Hemorrhoids is the most prevalent rectal disease. Despite different medical efforts, its complications are not managed well. In the present research, a popular prescription for treatment of hemorrhoids was formulated as tablet dosage form and, its HPTLC fingerprint prepared. Methods: Commiphora mukul was dissolved in Allium ampeloprasum juice (1:3). Then, this solution was blended with Terminalia chebula, Phyllantus emblica and Terminalia bellirica (1:1:1) powder. Different formulations were prepared from the mixture and the best one was selected for tablet preparation. Subsequently, the tablets were coated and their physicochemical characteristics and fingerprint pattern were obtained using silica gel plate, NP/PEG reagent and toluene: ethyl acetate: formic acid (70:15:15) as mobile phase. Laboratory stability studies were carried out as well. Results: Formulation C revealed excellent results in flowability studies (angle of repose: 26, carr’s index: 6, hausner ratio: 1.00). It was also demonstrated acceptable results in different tests including weight variation (500 mg), hardness (8.04 kg/cm2), disintegration time (28.50 min), friability (0.6%), dissolution (97.6% phenolics and 96.1% tannins, respectively) and the coating process. Total phenolics and tannins contents were determined as 125.8 mg/tab and 89.2 mg/tab, respectively. In fingerprinting study, characteristic spots of each species were distinguished. The film-coated tablets were stable in laboratory stability test. Conclusion: With reference to anti-inflammatory, astringent and wound healing roles of phenolics and tannins in hemorrhoids, the present tablets could be an appropriate candidate for hemorrhoids regarding its historical backgrounds.
کلیدواژه‌های انگلیسی مقاله Allium ampeloprasum, Commiphora mukul,hemorrhoids,Phyllantus emblica,Terminalia
نویسندگان مقاله Sahar Dehdari |
Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Homa Hajimehdipoor |
Traditional Medicine and Materia Medica Research Center and Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Somayeh Esmaeili |
Traditional Medicine and Materia Medica Research Center and Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Seyed Alireza Mortazavi |
Department of Pharmaceutics, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Rasool Choopani |
Department of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

نشانی اینترنتی http://www.rjpharmacognosy.ir/article_114156_0d414005ff7dca2cf59d6edcb2d524ce.pdf
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