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Analytical and Bioanalytical Electrochemistry، جلد ۱۴، شماره ۶، صفحات ۵۸۲-۵۹۷
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عنوان انگلیسی An Electrochemical Strategy for the Highly Sensitive Voltammetric Determination of a Cardiovascular β-Blocking Agent in Biological Fluids
چکیده انگلیسی مقاله In this report, different voltammetric tools such as cyclic, linear sweep, and square wave voltammetry were used to investigate acebutolol, a -blocker type of drug that is used to treat a variety of ailments, including cardiovascular disease, using a carbon paste electrode (CPE) under physiological environment. Under various phosphate buffer solutions, the voltammetric behavior of acebutolol displays two oxidation peaks and one reduction peak potentially within the range of -0.2 to 1.4 V, optimum results were obtained for pH 7.0. The electrode reaction was accompanied by two protons and two electrons transferred respectively; a probable electro-oxidation pathway has been proposed. The square wave voltammetric technique (SWV) was applied to perform a quantitative analysis of acebutolol. The linearity range was found to be between 0.06-10 µM. The LOD and LOQ were 2.06 nM and 6.88 nM, respectively which were superior to earlier methods. Furthermore, the new approach was used to determine the amounts of acebutolol in biological samples.
کلیدواژه‌های انگلیسی مقاله Drug analysis,Carbon paste electrode,Acebutolol,Voltammetry,Oxidation,Urine analysis and blood plasma
نویسندگان مقاله Manjunath Megalamani |
Department of Chemistry, School of Advanced Sciences, KLE Technological University, Hubballi, Karnataka, India

Yuvarajgouda Patil |
Department of Chemistry, School of Advanced Sciences, KLE Technological University, Hubballi, Karnataka, India

Jyothi C Abbar |
BMS Institute of Technology and Management, Bengaluru-560064, Affiliated to Visvesvaraya Technological University, Belagavi, Karnataka, India

Sharanappa Nandibeewoor |
Department of Chemistry, School of Advanced Sciences, KLE Technological University, Hubballi, Karnataka, India

نشانی اینترنتی https://www.abechem.com/article_253081_66d8c7866352e52cf4a0b6b19b8a008d.pdf
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