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Analytical and Bioanalytical Chemistry Research، جلد ۱۰، شماره ۴، صفحات ۳۹۵-۴۰۲
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عنوان انگلیسی Quantitative Determination of Clindamycin Phosphate in Gel Preparation Using PLSR Model
چکیده انگلیسی مقاله Quantitative determination of clindamycin by UV spectrophotometry is limited due to lack of UV chromophore of clindamycin structure. In this study, UV spectrophotometry employing partial least square regression (PLSR) model was developed with respect to high-performance liquid chromatography (HPLC) as the reference method for the quantitative determination of clindamycin phosphate in gel preparation. The successful PLSR model used UV spectral data in the region of 190  400 nm without data preprocessing. The leave-one-out cross- validation was utilized for model construction. The latent factor 2 was used in the final model with the R2 model of 0.9972, root mean square error of calibration (RMSEC) and root mean square error of cross-validation (RMSECV) of 0.0044 and 0.0048, respectively. Model ability was approved by quantitative determination of 20 validation samples that were not contributed in the model building step. Accuracy of determination results expressed in terms of root mean square error of prediction (RMSEP), the relative standard error of prediction (RSEP%) and bias were 0.0072, 0.0447% and -0.0025, respectively. This study demonstrated that PLSR assisted-UV spectrophotometry could be used as an alternative method for the quantitative determination of non-UV chromophore active pharmaceutical ingredients in the pharmaceutical dosage form.
کلیدواژه‌های انگلیسی مقاله Clindamycin phosphate gel,PLSR,Non-UV chromophore drug,chemometrics
نویسندگان مقاله Jiraporn Leanpolchareanchai |
Department of Pharmacy, Faculty of Pharmacy, Mahidol University, 447 SriAyutaya, Payathai, Rachathevee, Bangkok, 10400 Thailand

Napitchaya Jumniansuk |
Faculty of Pharmacy, Huachiew Chalermprakiet University, 18/18 Debaratna Rd, Bang Chalong, Bang Phli District, Samut Prakan 10540 Thailand

Chalida Saesoul |
Faculty of Pharmacy, Huachiew Chalermprakiet University, 18/18 Debaratna Rd, Bang Chalong, Bang Phli District, Samut Prakan 10540 Thailand

Rapee Sukthongchaikool |
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mahidol University, 447 SriAyutaya, Payathai, Rachathevee, Bangkok, 10400 Thailand

Chutima Phechkrajang |
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mahidol University, 447 SriAyutaya, Payathai, Rachathevee, Bangkok, 10400 Thailand

نشانی اینترنتی https://www.analchemres.org/article_171489_7f4aa3e9fb7fa50a77b7edcd54cd04d8.pdf
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