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Analytical and Bioanalytical Chemistry Research، جلد ۹، شماره ۱، صفحات ۵۹-۷۱
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عنوان انگلیسی Voltammetric Determination of Famotidine Using a Bilayer of Electrodeposited Gold Nanodendrites and Mercapto-propanioc Acid
چکیده انگلیسی مقاله Due to vital essence of medicine dosage monitoring within therapeutic range, a simple, rapid, high performance, sensitive and environmentally friendly electrochemical sensor was designed and used to diagnosis low concentrations of famotidine, a histamine-2 blocker, at pharmaceutical products and biological fluids. In this work, a simple, fast response and efficient voltammetic sensor was designed by using the functionalized dendrite-like gold nanostructures with 3-mercapto-propanioc acid (3-MPA/Au-DNSs). Electrochemical studies confirmed well the efficiency of the surface modified glassy carbon electrode (GCE) with 3-MPA/Au-DNSs on amplification of response signal in presence of famotidine in an applicable linear concentration range of 3.0 × 10−7–1.0 × 10−5 M. The limit of detection was evaluated to be 3.33 × 10−8 M (for S/N=3) under the optimum conditions. The modified GCE with 3-MPA/Au-DNSs was successfully applied in determination of famotidine in real samples such as human serum and pharmaceuticals with recoveries of 104.8 % and 100.90%, respectively.
کلیدواژه‌های انگلیسی مقاله Famotidine,Dendrite-like gold nanostructures,Electrochemical sensor,Serum sample
نویسندگان مقاله Haneie Salehniya |
Department of Chemistry, University of Mohaghegh Ardabili, Ardabil, Iran

Mandana Amiri |
Department of Chemistry, University of Mohaghegh Ardabili, Ardabil, Iran

Khadijeh Nekoueian |
Department of Chemistry, University of Mohaghegh Ardabili, Ardabil, Iran

نشانی اینترنتی https://www.analchemres.org/article_137002_be55e66117ab4640a4dd8a5ca3519a38.pdf
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