این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Analytical and Bioanalytical Chemistry Research، جلد ۸، شماره ۳، صفحات ۴۰۵-۴۱۵
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی A Simple Liquid Chromatographic Method for Estimation of Glycopyrrolate in Pharmaceuticals Using Experimental Design
چکیده انگلیسی مقاله A liquid chromatographic method was developed and validated to estimate glycopyrrolate (GLP) present in pharmaceutical formulations. The method was developed using a C18 column with a mobile phase involved methanol: phosphate buffer (pH=3.2) (65:35, %v/v) flowing at 1.0ml min-1. GLP was detected at a wavelength of 224nm. The method was found linear over a concentration range of 6-14µg ml-1. Degradation studies proved the chromatographic method specificity. Validation studies postulated method acceptability and suitability for estimating GLP in both bulk as well as injectables. The detection and quantitation limits were 2.5µg ml-1 and 6.0µg ml-1, respectively. Further, method precision was assured (%R.S.D. <2%) employing an experimental design approach using a factorial design. Also, it revealed that analyst skills are of critical importance and may influence the method preciseness. Overall the method was reliable and of optimum quality and possesses the potential of application in routine quality control of dosage forms of GLP and may serve as a basis for future bio-analytical method development purpose.
کلیدواژه‌های انگلیسی مقاله Anticholinergic,Factorial design,Injectables,Stability-indicating,Validation
نویسندگان مقاله Sagar Suman Panda |
Department of Pharmaceutical Analysis & Quality Assurance, Roland Institute of Pharmaceutical Sciences, Berhampur, Odisha, India

Ravi Kumar Venkata Varaha Bera |
Department of Pharmaceutical Analysis & Quality Assurance, Roland Institute of Pharmaceutical Sciences, Berhampur, Odisha, India

Raja Kumar Viriyala |
Grapes College of Pharmacy, Koyyalagudem, Andhra Pradesh, India

Suman Kumar Mekap |
Centurion University of Technology & Management, Khurda, Odisha, India.

نشانی اینترنتی https://www.analchemres.org/article_131052_92ee270851cd77f9ebb667db7c98f32c.pdf
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات