این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Analytical and Bioanalytical Chemistry Research، جلد ۸، شماره ۲، صفحات ۱۳۹-۱۴۵
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Reverse Phase HPLC Method for the Simultaneous Determination of Cetirizine, Verapamil/Diltiazem and Amlodipine
چکیده انگلیسی مقاله Determination of cetirizine, diltiazem, or verapamil and amlodipine in an active and in dosage formulations has been performed using a simple RP-HPLC method. Rosuvastatin is used in this novel RP-HPLC method as an internal standard to improve the selectivity of the method. At 230 nm, the separation was performed using a mobile phase consisting of methanol, acetonitrile, and water mixture in a ratio of 65:5:30, and pH at 2.8 allowed improved separation and faster times of analysis. ICH guidelines have pursued the validation of the method by assessing accuracy, precision (%RSD>2), and linearity (>0.999). The retention times of diltiazem, verapamil, amlodipine, cetirizine, and rosuvastatin was found to be 2.5, 3.2, 4.1, and 6 minutes, respectively. Method specificity was good as no interference of excipients of the tablets were observed in the analysis. The developed method could be used for routine quality control and in biological samples for the analysis of these drugs.
کلیدواژه‌های انگلیسی مقاله Cetirizine,Verapamil,Amlodipine,Rosuvastatin,RP-HPLC
نویسندگان مقاله Hina Shamshad |
Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, University of Karachi, Karachi, 75270, Pakistan

Asia Naz |
Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi

Agha Zeeshan Mirza |
Chemistry Department, Faculty of Applied Sciences, Umm Al-Qura University, Makkah, Saudi Arabia

نشانی اینترنتی https://www.analchemres.org/article_119158_22108759aa75569b249d4540e18ec49b.pdf
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات