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International Journal of Engineering، جلد ۳۴، شماره ۷، صفحات ۱۵۷۶-۱۵۸۵
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عنوان انگلیسی Spectrophotometric Determination of Naproxen Using Chitosan Capped Silver Nanoparticles in Pharmaceutical Formulation
چکیده انگلیسی مقاله Abstract
In this work, determination of naproxen concentration by chitosan capped silver nanoparticles were investigated. A new, simple and inexpensive spectrophotometric method for the first time was developed. The characteristics of chitosan capped silver nanoparticles were determined by ultraviolet spectroscopy (UV), Fourier transform infrared spectroscopy (FT-IR), atomic force microscopy (AFM), dynamic light scattering (DLS) and zeta potential (ZP) under optimal conditions. It worth to be mentioned that, synthesized chitosan (CS) -Ag nanoparticles were approximately 100 nm and PDI 0.385 with strong anionic (-24.8mV) zeta potential in acidic condition. It was found that chitosan as a chiral selector was able to detect naproxen at optimal experimental conditions. Validation of this method, including limit of detection and limit of quantification were accurately confirmed according to ICH instructions. Based on this method, the limit of detection (LOD) and the limit of quantification (LOQ) of naproxen were calculated 0.022 and 0.066 mol. L-1, respectively. Analysis of statistical data, the reproducibility and accuracy of this method demonstrated that the use of this novel method is valuable and practical for determination of naproxen in pharmaceutical formulations
کلیدواژه‌های انگلیسی مقاله Chitosan,Naproxen,Silver nanoparticle,UV- vis spectrophotometric determination,Characterization
نویسندگان مقاله A. Barazandeh |
Department of Chemical Engineering, Central Tehran Branch, Islamic Azad University, Tehran, Iran

G. D. Najafpour |
Faculty of Chemical Engineering Shariati Avenue, Babol Noshirvani University of Technology

A. Alihosseini |
Department of Chemical Engineering, Central Tehran Branch, Islamic Azad University, Tehran, Iran

S. Kazemi |
Department of Pharmacology and Physiology, School of Medicine, Babol University of Medical Sciences

نشانی اینترنتی https://www.ije.ir/article_132515_265eacb6cbf6a8bc691c82505dd39686.pdf
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