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Iranian Journal of Biotechnology، جلد ۲۰، شماره ۴، صفحات ۳۸-۴۷
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عنوان انگلیسی Phenotype Compensation in Reproductive ADAM Gene Family: A Case Study with ADAM27 Knockout Mouse
چکیده انگلیسی مقاله Background: A disintegrin and metalloproteinase (ADAM) cell surface proteins are expressed in different cells and are involved in biological processes such as cell-cell interactions, cell differentiation, sperm attachment and fertilization. A significant number of ADAM isoforms are expressed in the reproductive tracts of male mice and other mammals, which shows the importance of this gene family in reproduction.
Objectives: The role of ADAM27 protein in reproduction was investigated.
Materials and Methods: ADAM27 knock-out mutant mice were generated using the blastocyst microinjection technique. The knock-out mice were analyzed genetically and phenotypically to discover any abnormalities.
Results: The results of this study revealed that the homozygote mutant male mice were fertile and showed no significant differences compared to wild-type male mice. A histological exam, sperm analysis and in-vitro fertilization experiments showed no statistical differences.
Conclusions: We can conclude that the role of deficient ADAM27 protein is probably compensated mainly by other ADAM isoforms which are expressed in the reproductive system.
کلیدواژه‌های انگلیسی مقاله ADAM27,Fertility,Knockout mouse
نویسندگان مقاله Jafar Khezri |
Department of Animal Biotechnology, Faculty of Agriculture Biotechnology, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran

Ehsan Hashemi |
Department of Animal Biotechnology, Faculty of Agriculture Biotechnology, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran

Mehdi Shamsara |
Department of Animal Biotechnology, Faculty of Agriculture Biotechnology, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran

Aidin Rahim Tayefeh |
Department of Animal Biotechnology, Faculty of Agriculture Biotechnology, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran

Farid Heidari |
Department of Animal Biotechnology, Faculty of Agriculture Biotechnology, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran

نشانی اینترنتی https://www.ijbiotech.com/article_157958_4e266d15c62a0b870839af946926541f.pdf
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