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Iranian Journal of Chemistry and Chemical Engineering، جلد ۴۱، شماره ۳، صفحات ۸۵۳-۸۶۵
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عنوان انگلیسی Efficient and Scalable Methods for Synthesis of Midazolam Drug with an Annulation Process
چکیده انگلیسی مقاله The reported methods for the synthesis of midazolam include a number of disadvantages, such as high production costs and low yields. The purpose of this investigation was to develop a more economical and technically feasible route to the synthesis of midazolam. In this research, two easy and scalable synthetic methods for the production of midazolam drugs are presented. One-pot condensation of imidoyl chloride or 1,4-benzodiazepinic N-nitrosoamidines with carbanion of two isocyanide reagents is described and two important and key tricyclic ring intermediates are synthesized. These imidazole-type structures can be derivatives by the alkylation of the imidazole ring with tert-butyl magnesium chloride at 0 °C in excellent yield, which has not been described for these intermediates in the literature. 
کلیدواژه‌های انگلیسی مقاله Midazolam,Imidoyl chlorides,1,4-Benzodiazepinic N-nitrosoamidines,Imidazobenzodiazepine,Tosylmethyl isocyanide,Ethyl isocyanoacetate,Cyclization
نویسندگان مقاله Mohammad Javad Taghizadeh |
Imam HussDepartment of Chemistry, Faculty of Science, University of Imam Hossein, Tehran, I.R. IRANein University

Esmaile Chardolie |
Department of Chemistry, Faculty of Science, University of Imam Hossein, Tehran, I.R. IRAN

Gholam Reza Malekpoori |
Department of Chemistry, Faculty of Science, University of Imam Hossein, Tehran, I.R. IRAN

نشانی اینترنتی https://ijcce.ac.ir/article_242825_da91ac9ef74cf87c728ba04aeaffa3ac.pdf
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