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JCR 2016
جستجوی مقالات
دوشنبه 24 آذر 1404
Iranian Journal of Chemistry and Chemical Engineering
، جلد ۴۰، شماره ۵، صفحات ۱۶۳۰-۱۶۴۱
عنوان فارسی
چکیده فارسی مقاله
کلیدواژههای فارسی مقاله
عنوان انگلیسی
Quantum Chemical and Experimental Exploration of Biological Activity and Inhibitory Potential of New Acylated Oligosaccharides from Pistacia integerrima J. L. Stewart ex Brandis
چکیده انگلیسی مقاله
The
new biologically active integrisides A (
1
) and B (
2
) have been isolated from the methanolic extract of
Pistacia integerrima J. L. Stewart ex Brandis
.
The antibacterial activity of both the
integrities
was tested against four pathogenic bacterial strains, two Gram-positive (Staphylococcus aureus, Streptococcus pyogenes) and two Gram-negative (Escherichia coli, Pseudomonas aeruginosa) as well as
f
our fungal strains (
Microsporum canis,
Aspergillus clavatus, Candida albicans, and Candida glabrata). Both the isolated compounds showed significant results analogous with
Imipenam
and
Miconazole
standard drugs.
Carbonic
anhydrase-II
i
nhibition
of
integriside
A
(
1
)
and
B
(
2
)
with
IC
50
value
1.56 µM and 2.85 µM respectively, as compared to standard drug acetazolamide
(
1.57 µM)
.
Cholinesterase
activity was carried out with
acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)
IC
50
value
s
of integriside A
(
1
)
(
8.6, 4.8)
and
B
(
2
)
(0.91, 2.5) were found as compared with standard galanthamine
(0.05, 0.92) and Eserine
(0.6, 8.7). Here, various molecular descriptors, frontier molecular orbitals (FMO), electron affinity (E.A), ionization potential (IP), molecular electrostatic potential (MEP), and Hirshfeld analysis were carried out to understand the active sites and biological active nature of the
integriside
s
A
(
1
)
and
B
(
2
)
.
The energy gap, MEP, Hirshfeld analysis, and reactivity descriptors values demonstrate that the
integriside
A
(
1
)
and
B
(
2
)
retain decent reactivity, which is in good agreement with current experimental
and quantum chemical studies
.
کلیدواژههای انگلیسی مقاله
Pistacia integerrima J. L. Stewart ex Brandis,Integrisides,Cholinesterase activity,Antimicrobial activity,Quantum chemical study
نویسندگان مقاله
Ahmad Irfan |
Research Center for Advanced Materials Science, King Khalid University, P.O. Box 9004, Abha 61413, SAUDI ARABIA
Sajjad Hussain Sumrra |
Department of Chemistry, University of Gujrat, 50700, PAKISTAN
Muhammad Imran |
Department of Chemistry, Faculty of Science, King Khalid University, P.O. Box 9004, Abha 61413, SAUDI ARABI
Mohammed Ali Assiri |
Department of Chemistry, Faculty of Science, King Khalid University, P.O. Box 9004, Abha 61413, SAUDI ARABI
Noreen Khalid |
Department of Pharmaceutical Chemistry, College of Pharmacy, University of Sargodha, PAKISTAN
Abdullah Ghodran Al-Sehemi |
Research Center for Advanced Materials Science, King Khalid University, P.O. Box 9004, Abha 61413, SAUDI ARABIA
نشانی اینترنتی
https://ijcce.ac.ir/article_40536_1bb53683b59d8d4dcb09a2c698c53424.pdf
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