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Physical Chemistry Research، جلد ۱۲، شماره ۱، صفحات ۱۴۵-۱۵۶
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عنوان انگلیسی Coupling Interaction of Ampicillin Drug with Ninhydrin in Aqueous Acidic Medium: Kinetics and Mechanistic Studies
چکیده انگلیسی مقاله The Kinetics of Ninhydrin (Nin) reaction with Ampicillin (Amp) has been studied in an aqueous acidic medium. The product of the reaction was examined spectroscopically using Nuclear magnetic resonance (1H-NMR) and Infrared spectra in addition to Ultra-performance liquid chromatography (UPLC). The reaction was monitored spectrophotometrically, with (0.1- 0.4) × 10-4 mol dm-3 of Amp, (0.5-5.0) ×10-2 mol dm-3 Nin and 0.3- 0.9 mol dm-3 ionic strength (I) over the (30-50) °C range of temperature. It is first order with respect to [Nin] and [Amp], decreases as pH increases in the range (4.70 -6.04). The effect of the catalyst on the rate of the reaction was studied. The thermodynamics activation parameters involving ∆H* and ∆S* have been calculated. The rate of the reaction follows the rate law d[Amp-Nin]/dt ={k2 + (k4+k3[H+])[Nin]}×[ Amp]. For this reaction is proposed mechanism was supported by an excellent isokinetic relationship between ∆H* and ∆S* for some Nin reactions. In emergency :case when: posing with Amp about 30% of the oral dose is excreted in urine in 6 hours as unchanged drug, so a presumptive colour test is necessary in clinical toxicology. Then, using Nin to form a coupling complex with Amp is an effective method.
کلیدواژه‌های انگلیسی مقاله Kinetics,Reaction mechanism,ninhydrin,Ampicillin
نویسندگان مقاله Taha Abdelgalil Ibrahim |
Expert in Forensic Medicine Authority, Cairo-Egypt

Ahmed Ahmed Abdel-Khalek |
Chemistry Department, Faculty of science, Beni-Suef University

Mahmoud Mohamed Abdel-Hafeez |
Forensic Medicine Authority, Cairo, Egypt

Reham Anwar Mohamed |
Chemistry Department, Faculty of Science, Bani-Suef University

Eman Saber Hassan |
Chemistry Department, Faculty of Science, Bani-Suef University

نشانی اینترنتی https://www.physchemres.org/article_172373_873984d3eacf2d4ffdffae4efc70eccb.pdf
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