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Physical Chemistry Research، جلد ۱۱، شماره ۳، صفحات ۶۲۳-۶۲۹
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عنوان انگلیسی Monoclonal Antibodies as Potential Treatment Drugs for Nsp15 and 3CLpro Proteins
چکیده انگلیسی مقاله Selected monoclonal antibody molecules were conducted using the antibody–antigen docking mode, as well as the antibody-antigen docking approach.Objective of the study was to check effects of CetuximabCOVID-19 proteins (Nsp15 and 3CLpro) by using antibody–antigen docking mode, as well as the antibody-antigen docking approach.The results of molecular docking revealed that Cetuximab, a cancer-fighting antibody, ranks first among antibodies to both COVID-19 proteins (Nsp15 and 3CLpro).In cetuximab–3CLpro and cetuximab–Nsp15 complexes, the antigen interacts with both antibody chains, H and L.According to the findings, Cetuximab can be added to the COVID-19 treatment protocol, which may have the desired effect of inhibiting viral replication and decreasing mortality by targetingCOVID-19 proteins (Nsp15 and 3CLpro).Validation of these computational findings will require additional in vitro and in vivo research, which can be considered as a contribution in the field of biotechnology
کلیدواژه‌های انگلیسی مقاله COVID-19,Antibody-Antigen docking,cetuximab
نویسندگان مقاله Shifaa O. Alshammari |
Department of Biology, College of Science, University of Hafr Albatin, P. O. Box: 1803, Hafr Al Batin, Saudi Arabia

Ghassab M. Al-Mazaideh |
Department of Pharmaceutical Chemistry, College of Pharmacy, University of Hafr Al Batin, P. O. Box: 1803, Hafr Al Batin 31991, Saudi Arabia

Fadi Alakhras |
College of Pharmacy, Middle East University, Amman, 11831, Jordan

Mohammed Ayed Huneif |
Department of Pediatrics, College of Medicine, Najran University, Najran, Saudi Arabia

Syed Imran Ali Shah |
Department of Biochemistry, CMH Lahore Medical College & Institute of Dentistry, Lahore, Pakistan

Ashfaq Ahmad |
College of Pharmacy, University of Hafr Al Batin, Kingdom of Saudi Arabia

Haya Ayyal Salman |
School of Biological Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia

Mohammed Helmy Faris Shalayel |
Professor of Biochemistry, Department of Pharmacy Practice, University of Hafr Al Batin, Saudi Arabia

نشانی اینترنتی https://www.physchemres.org/article_158452_15f5ecbb5334c4f00a71cb5755230765.pdf
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