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Physical Chemistry Research، جلد ۱۱، شماره ۳، صفحات ۶۷۵-۶۸۲
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عنوان انگلیسی Solubility of Lamotrigine in Polyethylene Glycol 400 + 2-Propanol Mixtures at Different Temperatures
چکیده انگلیسی مقاله In this study, the shake-flask method was used to determine the solubility of lamotrigine (LTG) in non-aqueous mixtures of polyethylene glycol 400 (PEG 400) and 2-propanol at temperatures of 293.15 to 313.15 K. Five main mathematical models were used to correlate the experimental data. The overall mean relative deviations for these models were less than 18.7 %. In addition, the apparent thermodynamic properties of LTG dissolution were computed. It is found that the LTG dissolution in PEG 400-rich mixtures is more favorable and proceeds entropically. Both experimental and mathematical methods were used to determine the density of LTG-saturated solutions. The results showed that the Jouyban–Acree model could be used to predict the density of LTG saturated solutions in mixtures with a very good approximation (back-calculated MRD% of 0.4).
کلیدواژه‌های انگلیسی مقاله Solubility,lamotrigine,Cosolvency models,Dissolution thermodynamics
نویسندگان مقاله Atefeh Sheikhi-Sovari |
Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran

Behrouz Seyfinejad |
Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran

Hongkun Zhao |
College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu 225002, People’s Republic of China

Elaheh Rahimpour |
Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran. Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Abolghasem Jouyban |
Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran. Faculty of Pharmacy, Near East University, P. O. Box: 99138 Nicosia, North Cyprus, Mersin 10, Turkey

نشانی اینترنتی https://www.physchemres.org/article_159654_8d8dff01816153c1b08bc3bc2ffc99de.pdf
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