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Veterinary Research Forum، جلد ۱۴، شماره ۱، صفحات ۴۵-۵۲
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عنوان انگلیسی Association between uterine toxicity induced by chlorpyrifos and downregulation of heparin-binding epidermal growth factor and L-selectin genes
چکیده انگلیسی مقاله Various factors are effective in reducing the fertility rate. This experiment aimed to investigate chlorpyrifos (CPF), an organophosphate, that could alter the structure of the uterus and the molecules involved in parental and fetal. CPF was injected intraperitoneally in thirty mice for five days in a week (six weeks). The animals were euthanized on the 5th day of gestation, then their blood and uterus were collected for biochemical and histopathological assays. Exposure to CPF resulted in a significant reduction in maternal weight gain and the number of litters. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) were significantly increased in blood serum of the CPF group compared with the control. The number of uterus glands, endometrium thickness, and the uterine cavity were changed following CPF injection. Additional investigation indicated that the expressions of L-selectin, L-selectin ligand, and heparin-binding epidermal growth factor (HB-EGF) as initial adhesion of mice blastocysts and maternal endometrium biomarkers were downregulated in the CPF group. Nevertheless, any mortality and abnormal clinical symptoms were not observed in the treated mice. This study revealed a potential molecular mechanism of continuous CPF-induced toxicity in fetal-maternal attachment without clinical symptoms.
کلیدواژه‌های انگلیسی مقاله Adhesion Molecules,Endometrium,Liver enzymes
نویسندگان مقاله Parisa Gheibi |
Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran

Zohre Eftekhari |
Biotechnology Department, Pasteur Institute of Iran, Tehran, Iran

Delaram Doroud |
Department of Quality Control, Research and Production Complex, Pasteur Institute of Iran, Karaj, Iran

Kazem Parivar |
Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran

نشانی اینترنتی https://vrf.iranjournals.ir/article_697962_b64ee0f8f9f20ec6d8c39eca0ea2dfb7.pdf
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