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Veterinary Research Forum، جلد ۱۲، شماره ۳، صفحات ۳۳۳-۳۳۸
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عنوان انگلیسی Ethephon causes reproductive malfunction in adult male mice: Histological ‎and biochemical evidence
چکیده انگلیسی مقاله Ethephon (C2H6ClO3P; ETP), an organophosphorus pesticide regulating plant growth, is widely used for early ripening of fruits and vegetables in agriculture. The aim of this study was to investigate the effects of ETP on histomorphometrical and biochemical parameters in mouse testicular tissue. In this study, 90 adult male mice were randomly divided into six equal groups (n = 15). The ETP was administered orally at different doses (120, 240 and 480 mg kg-1) daily for 35 days. Untreated control, sham (received only normal saline) and neostigmine bromide-treated (positive control; 0.10 mg kg-1 orally; once per week) groups were also considered. Following 35 days, animals were euthanized and testicle and serum samples were taken. Accordingly, blood and serum acetylcholinesterase (AChE), catalase, total antioxidant capacity (TAC) and malondialdehyde (MDA) levels as well as histomorphometrical changes of testicles were investigated. The ETP-administered animals represented a significant reduction in AChE, TAC and catalase levels and remarkable increment in MDA content. A marked reduction was also seen in the germinal epithelium height, connective tissue thickness, seminiferous tubules diameter and Leydig cell number as well as spermiogenesis and Sertoli cell indices in ETP-treated mice compared to control ones. Similar findings were found in neostigmine bromide-treated animals. In conclusion, the ETP significantly affects the serum and blood anti-oxidant statuses and results in severe histological damages both at germ and somatic cell levels, suggesting its hematotoxic and reprotoxic characteristic.
کلیدواژه‌های انگلیسی مقاله Ethephon,‎ Hematotoxicity,‎ Histomorphometry,‎ Oxidative stress,‎ Testis
نویسندگان مقاله Ramin Jahangirfard |
PhD Candidate, Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran‎

Gholamreza Najafi |
Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran

Ali Shalizar-Jalali |
Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran

Abbas Ahmadi |
Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran

Elham Zadehhashem |
Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran

نشانی اینترنتی https://vrf.iranjournals.ir/article_244414_b901f9edcc6750cf69a12b2a5711dc5b.pdf
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