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Veterinary Research Forum، جلد ۱۲، شماره ۱، صفحات ۴۷-۵۲
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عنوان انگلیسی Molecular effects of curcumin on the experimental autoimmune ‎encephalomyelitis
چکیده انگلیسی مقاله Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis (MS). Previous studies have shown that myelin degradation during MS and EAE resulted in reduced expression of some of the proteins, e.g., the MBP (myelin basic protein), and increased expression of genes such as iNOS (Inducible nitric oxide synthase) and NOGO-A in the affected patients. In the present study, EAE was induced by immunizing Wistar rats (n=12) with homogenized spinal cord of guinea pig and Freund's complete adjuvant. Curcumin is an active ingredient in turmeric with anti-inflammatory properties, which has been studied in this article. In this study, the effect of curcumin administration on the change of the expression of MBP, NOGO-A, and iNOS genes was evaluated using the RT-PCR (Reverse transcription-polymerase chain reaction) technique. The obtained results indicated it could be concluded that curcumin was able to improve EAE by increasing the amount of MBP gene expression and reducing the intensity of NOGO-A expression.
کلیدواژه‌های انگلیسی مقاله curcumin,‎ Encephalomyelitis,‎ Multiple sclerosis,‎ RT PCR
نویسندگان مقاله Laleh Mavaddatiyan |
Department of Biology, Faculty of Sciences, Urmia University, Urmia, Iran

Shiva Khezri |
Department of Biology, Faculty of Sciences, Urmia University, Urmia, Iran

Seyyed Meysam Abtahi Froushani |
Department of Microbiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran

نشانی اینترنتی https://vrf.iranjournals.ir/article_240929_326d728b3cba23c212d3f3170a45f9c9.pdf
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