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Veterinary Research Forum، جلد ۱۱، شماره ۴، صفحات ۳۵۵-۳۶۳
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عنوان انگلیسی Use of ovine acellular peritoneal matrix combined with honey and ovine fetal ‎skin extract in the healing of full-thickness infected burn wounds in a rat ‎model
چکیده انگلیسی مقاله Treatment of infected burn wounds remains a challenge in burn units. Silver-sulfadiazine (SSD) is the most commonly used topical antimicrobial agent in managing these wounds. We aimed to accelerate the healing of burn wounds by combined application of ovine acellular peritoneal matrix (OAPM), honey (H), and ovine fetal skin extract (OFSE). Sixty-four standardized burn wounds were created on the dorsum of 16 rats and were subsequently inoculated with Staphyloccocus aureus and Pseudomonas aeruginosa. After 48 hr, the wounds were surgically debrided and received either physiologic saline (control group) or SSD, OAPM+SSD, OAPM+H+SSD, OAPM+H+OFSE+SSD. The healing wounds were evaluated for size, bacterial counts, histopathology, and biomechanical properties on days 3, 7, 14, 21, and 28 after surgery. All treatments had effectively reduced the level of S. aureus and P. aeruginosa on wounds compared to the control group by day 3 and 7. The wounds treated with combined application of OAPM+H+OFSE+SSD demonstrated considerable inflammation reduction, fibroplasia, complete re-epithelialization, and wound contraction together with significantly lesser scar tissue formation. Treatment with OAPM+H+OFSE+SSD showed superior biomechanical properties of the healing wounds. The findings suggested that the synergistic effect of dressing the wounds with OAPM, H, and OFSE was a very effective approach in accelerating the healing process of the experimentally induced infected full-thickness burn wounds in rats.
کلیدواژه‌های انگلیسی مقاله Acellular matrix,‎ Burn wounds,‎ Fetal skin extract,‎ Honey,‎ Wound healing
نویسندگان مقاله Behrouz Nikahval |
Department of Clinical Studies, School of Veterinary Medicine, Shiraz University, Shiraz, Iran

Ahmad Oryan |
Department of Pathology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran

Parastoo Memarian |
Department of Clinical Studies, School of Veterinary Medicine, Shiraz University, Shiraz, Iran

Amir Kamali |
Department of Pathology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran

نشانی اینترنتی https://vrf.iranjournals.ir/article_45632_168f0487ba6bc04807b92f1ecf7106c1.pdf
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