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Veterinary Research Forum، جلد ۱۱، شماره ۲، صفحات ۱۲۷-۱۳۴
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عنوان انگلیسی Comparison of the effects of hydroalcoholic extract of <i>Capparis spinosa</i> fruit, quercetin and vitamin E on monosodium glutamate-induced toxicity in rats
چکیده انگلیسی مقاله Capparis spinosa L. has many biological effects such as antioxidant properties. In the present study, we compared the effects of the hydro-alcoholic extract of Capparis spinosa fruit, quercetin (Q), and vitamin E (Vit E) on monosodium glutamate (MSG)-induced toxicity. The following groups were designed: Control groups (normal saline and/or corn oil); MSG group (4.00 g kg-1 MSG); MSG + low dose extract group (4.00 g kg-1 MSG with 100.00 mg kg-1 extract); MSG + high dose extract (HDE) group (4.00 g kg-1 MSG with 300.00 mg kg-1 extract); MSG + Q group (4.00 g kg-1 MSG with 10.00 mg kg-1 Q); MSG + Vit E group (4.00 g kg-1 MSG with 200.00 mg kg-1 Vit E). All chemicals were orally administered for 14 consecutive days. Tissue specimens from the heart, kidney, and liver tissues and blood samples were collected for histopathological and biochemical evaluations. The results showed that the MSG-induced tissue edema, congestion, and inflammatory cell infiltration were resolved by HDE, Q, and Vit E treatments. These chemicals also restored tissue malondialdehyde level and superoxide dismutase activity. Besides, alterations induced by MSG in serum levels of aspartate transaminase, alanine aminotransferase, urea, lactate dehydrogenase, and creatine kinase-MB were also resolved. It is concluded that Capparis spinosa fruit extract, Q and Vit E can produce approximately similar protective effects on tissue function through oxidative stress alleviation and antioxidant mechanisms restoration.
کلیدواژه‌های انگلیسی مقاله Capparis spinosa, Monosodium glutamate, Quercetin, Toxicity, Vitamin E
نویسندگان مقاله Navideh Mirzakhani |
Department of Pathobiology, Faculty of Veterinary Medicine, Amol University of Special Modern Technologies, Amol, Iran

Amir Abbas Farshid |
Department of Pathobiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran

Ali-Asghar Tehrani |
Department of Pathobiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran

Esmaeal Tamaddonfard |
Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran

Mehdi Imani |
Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran

نشانی اینترنتی http://vrf.iranjournals.ir/article_39696_1d846c02eaa069c7e84d073669212b91.pdf
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