Background and purpose: Human papillomavirus (HPV) is a tiny virus of the papillomavirus family that infects skin and mucosal cells and can be transmitted through sexual intercourse. In general, all STIs (Sexually Transmitted Diseases) have negative psychological effects. In addition, the diagnosis of HPV has a wide impact on the mental health of patients and their sexual activity, which may make the patient feel ashamed and disrupt the patient's relationship with his life partner. The level of anxiety and sexual satisfaction has not been measured in women with HPV in Iran, yet. Therefore, the purpose this study was to investigate their awareness of the HPV virus and its relationship with the level of anxiety and sexual satisfaction of the patients with a positive HPV test.