این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Journal of Medicinal Plants and By-products، جلد ۱۲، شماره ۲، صفحات ۱۹۱-۱۹۶
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Evaluation of Antibacterial, Antibiofilm and Cytotoxicity Effect of Crude Ethanolic Extract of Cuminum cyminum Against Streptococcus mutans
چکیده انگلیسی مقاله Although, oral health is important for its role in the overall health but oral health care does not have an integrated model. So, today meeting the needs of oral health requires strong interactions between health research policy and oral health researchThe aim of this study investigates the effects of ethanolic crud extract of Cuminum cyminum L. on S. mutans in terms of antibacterial, antibiofilm and, its cytotoxicity properties. The present experimental study which has conducted in 2019-2020. The crude alcoholic extract of C. cyminum seeds was prepared by the maceration method. Then, the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of crude ethanolic extract of C. cyminum was determined by micro-dilution method according to CLSI protocol on Streptococcus mutans (PTCC1683). In addition, its antibiofilm effect was investigated by the previous method using crystal violet. As well, an MTT test was performed to evaluate its cytotoxicity on SW480 cells. Statistical analysis was done by SPSS V.22 software. MIC and MBC concentrations of C. cyminum extract on S. mutans were found to be 0.62 mg/mL and 1.25 mg/mL. The effect of inhibiting biofilm production was also observed at a concentration of 40 mg/mL.  In MTT assay showed a greater cytotoxic effect on SW480 cancer cells at higher concentrations for longer periods of time. The present study showed that the cumin ethanolic crude extract has antimicrobial properties, inhibits the growth of S. mutans biofilms and has no toxic properties. MIC: minimum inhibitory concentration. MBC: minimum bactericidal concentration. MTT: 3-(4,5-dimethylthiazol-2-yl) -2,5-diphenyl-2H- tetrazolium bromide. DMSO: dimethyl sulfoxide
کلیدواژه‌های انگلیسی مقاله cumin, dental carriers, biofilm, S. mutans
نویسندگان مقاله Elham Osanloo |
Department of Pediatric Dentistry, School of Dentistry, Shahid Beheshti University of Medical Sciences (SBMU) Tehran, Iran

Ali Asghar Soleymani |
Department of Pediatric Dentistry, School of Dentistry, Shahid Beheshti University of Medical Sciences (SBMU) Tehran, Iran

Marziyeh Taheri |
Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences (SBMU) Tehran, Iran

Sareh Sadat Hosseini |
Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences (SBMU) Tehran, Iran

Fatemeh Javadi |
Department of Pediatric Dentistry, School of Dentistry, Shahid Beheshti University of Medical Sciences (SBMU) Tehran, Iran

Mohammadmahdi Karimi-Yazdi |
Faculty of Paramedical Sciences, Mazandaran University of Medical Sciences, Sari, Iran

Majid Agha Gholizadeh |
Department of Pediatric Dentistry, School of Dentistry, Shahid Beheshti University of Medical Sciences (SBMU) Tehran, Iran

Mojdeh Hakemi-Vala |
Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences (SBMU) Tehran, Iran

نشانی اینترنتی https://jmpb.areeo.ac.ir/article_125599_b3a84b1360f4fa822d594c929aa2abb8.pdf
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات