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Acta Medica Iranica، جلد ۵۴، شماره ۱۰، صفحات ۶۳۱-۶۳۹
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عنوان انگلیسی Erythrocytes Membrane Alterations Reflecting Liver Damage in CCl₄-Induced Cirrhotic Rats: The Ameliorative Effect of Naltrexone
چکیده انگلیسی مقاله Cirrhosis is the consequence of chronic liver disease. Deleterious effects of oxidative stress on hepatocytes may be reflected in the erythrocyte membrane. Naltrexone (NTX) has been shown to attenuate hepatocellular injury in fibrotic animal models. The aim of this study was to investigate the progressive effect of CCl 4 on the liver and whether the improvement of liver cirrhosis can be monitored through alterations in the erythrocyte membrane. In this study, 84 male Wistar rats were divided into 4 groups and received reagents (i.p.) as follows: 1- CCl₄, 2- NTX + CCl₄, 3- Mineral Oil (M), and 4- NTX + M. After 2, 6 and 8 weeks, the blood and liver tissue samples were collected. Plasma enzyme activities, the content of erythrocyte GSH and some membrane compositions, including protein carbonyl, protein sulfhydryl, and malondialdehyde were assessed. After 6 and 8 weeks, plasma enzyme activities and the content of protein carbonyl were higher in CCl 4 group significantly, as compared to other groups ( P < 0.001). NTX significantly diminished protein carbonyl and plasma enzyme activities ( P < 0.001). GSH did not change until the 6 th week. However, CCl 4 +NTX increased it significantly as compared to CCl₄ group ( P < 0.05). Protein sulfhydryl showed changes in NTX+CCl₄ group which indicated a significant increase in protein sulfhydryl content in a 6 th week compared to CCl 4 group ( P < 0.05). MDA did not show any significant alteration. CCl₄-induced cirrhosis is accompanied by increased content of oxidative stress markers, especially protein carbonyl of RBC membrane and plasma enzyme activities. This study shows that the progression of liver cirrhosis and the ameliorative effect of NTX can be followed through alterations of these markers.
کلیدواژه‌های انگلیسی مقاله Cirrhosis,Carbon tetrachloride,Naltrexone,Oxidative stress
نویسندگان مقاله فاطمه سرحدی kholari | fatemeh sarhadi kholari
department of clinical biochemistry, school of medicine, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

احمد رضا دهپور | ahmad reza dehpour
department of pharmacology, school of medicine, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

میترا نوربخش | mitra nourbakhsh
department of clinical biochemistry, school of medicine, iran university of medical sciences, tehran, iran. and metabolic disorders research center, endocrinology and metabolism research institute, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

امیر حسین دوستی مطلق | amir hossein doustimotlagh
department of clinical biochemistry, school of medicine, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

مولود باقریه | molood bagherieh
department of clinical biochemistry, school of medicine, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

ابوالفضل گلستانی | abolfazl golestani
department of clinical biochemistry, school of medicine, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/5169
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