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Acta Medica Iranica، جلد ۵۴، شماره ۹، صفحات ۵۶۲-۵۶۹
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عنوان انگلیسی Subarachnoid Space Transplantation of Schwann and/or Olfactory Ensheathing Cells Following Severe Spinal Cord Injury Fails to Improve Locomotor Recovery in Rats
چکیده انگلیسی مقاله Treatment of spinal cord injury by exogenous cells has brought both successful and unsuccessful results. Olfactory ensheathing cells and Schwann cells have been widely used for transplantation purposes. In this study, we investigated the effects of these cells on contused spinal cord by introducing cells into subarachnoid space. Fifty thousand Schwann cells or olfactory ensheathing cells or a mixture of both cell types were transplanted one week after a 3-second clip compression injury at T-9 spinal cord level in rats. Starting from the day one of spinal cord injury, animals were assessed for six months by BBB test and then were sacrificed for immunohistochemistry labeling of the spinal cord injury site. There was no locomotor recovery in any of the treatment groups including controls. Immunohistochemistry assessment indicated positive labeling of P75 and S100 markers in the cell-transplanted groups compared with control. Our data suggest that transplantation of Schwann cells and/or olfactory ensheathing cells into the subarachnoid space does not improve motor recovery in severely injured spinal cord, at least with the number of cells transplanted here. This, however, should not be regarded as an essentially negative outcome, and further studies which consider higher densities of cells are required.
کلیدواژه‌های انگلیسی مقاله Spinal cord compression,Cell therapy,Behavioral recovery
نویسندگان مقاله محسن ناطق | mohsen nategh
tissue repair lab, institute of biochemistry and biophysics ibb , university of tehran, tehran, iran.

سازمان اصلی تایید شده: مرکز تحقیقات بیوشیمی و بیوفیزیک (Institute of biochemistry and biophysics)

معصومه فیروزی | masoumeh firouzi
tissue repair lab, institute of biochemistry and biophysics ibb , university of tehran, tehran, iran.

سازمان اصلی تایید شده: مرکز تحقیقات بیوشیمی و بیوفیزیک (Institute of biochemistry and biophysics)

مهدی ناجی تهرانی | mehdi naji tehrani
tissue repair lab, institute of biochemistry and biophysics ibb , university of tehran, tehran, iran.

سازمان اصلی تایید شده: مرکز تحقیقات بیوشیمی و بیوفیزیک (Institute of biochemistry and biophysics)

لیلا اوریادی زنجانی | leila oryadi zanjani
tissue repair lab, institute of biochemistry and biophysics ibb , university of tehran, tehran, iran.

سازمان اصلی تایید شده: مرکز تحقیقات بیوشیمی و بیوفیزیک (Institute of biochemistry and biophysics)

زهرا حسن نژاد | zahra hassannejad
tissue repair lab, institute of biochemistry and biophysics ibb , university of tehran, tehran, iran. and sina trauma and surgery research center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: مرکز تحقیقات بیوشیمی و بیوفیزیک (Institute of biochemistry and biophysics)

محمد حسین نبیان | mohammad hosein nabian
tissue repair lab, institute of biochemistry and biophysics ibb , university of tehran, tehran, iran.

سازمان اصلی تایید شده: مرکز تحقیقات بیوشیمی و بیوفیزیک (Institute of biochemistry and biophysics)

شایان عبدالله زادگان | shayan abdollah zadegan
tissue repair lab, institute of biochemistry and biophysics ibb , university of tehran, tehran, iran. and sina trauma and surgery research center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: مرکز تحقیقات بیوشیمی و بیوفیزیک (Institute of biochemistry and biophysics)

مهربد کریمی | mehrbod karimi
pathology lab, atie hospital, tehran, iran.


وفا رحیمی موقر | vafa rahimi movaghar
sina trauma and surgery research center, tehran university of medical sciences, tehran, iran. and brain and spinal injuries research center basir , tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/5131
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