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Acta Medica Iranica، جلد ۵۴، شماره ۸، صفحات ۵۵۱-۵۵۴
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عنوان انگلیسی Warfarin-Induced Skin Necrosis in Patients With Low Protein C Levels
چکیده انگلیسی مقاله Warfarin-induced skin necrosis (WISN) is a rare complication of anticoagulant therapy associated with a high incidence of morbidity and mortality requiring immediate drug cessation. At particular risk are those with various thrombophilic abnormalities, especially when warfarinisation is undertaken rapidly with large loading doses of warfarin. Cutaneous findings include petechiae that progress to ecchymosis and hemorrhagic bullae. With the increasing number of patients anticoagulated as out-patients for thromboprophylaxis, we are concerned that the incidence of skin necrosis may increase. We present a case of WISN with low protein C level. He was a 50-year-old male who came to our department because of acute infarction in irrigation area of the superior cerebellar artery. He had intermittent atrial fibrillation and was started on anticoagulant therapy. After few day of therapy, he developed skin necrosis, and his level of protein C was low. Warfarin-induced skin necrosis is a rare but serious complication that can be prevented by routine screening for protein C, protein S or antithrombin deficiencies or for the presence of antiphospholipid antibodies before beginning warfarin therapy.
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نویسندگان مقاله marino marčić | marino marčić
department of neurology, school of medicine, university of split, split, croatia.


ljiljana marčić | ljiljana marčić
department of radiology, school of medicine, university of split, split, croatia.


مارینا titlić | marina titlić
department of neurology, school of medicine, university of split, split, croatia.
نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/5013
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Case Report(s)
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