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Acta Medica Iranica، جلد ۵۴، شماره ۶، صفحات ۳۷۶-۳۸۱
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عنوان انگلیسی In Vitro Antifungal Susceptibility Profiles of Candida albicans Complex Isolated from Patients with Respiratory Infections
چکیده انگلیسی مقاله Candidiasis , the main opportunistic fungal infection has been increased over the past decades. This study aimed to characterize C.albicans species complex ( C.albicans , C.dubliniensis , and C.africana ) isolated from patients with respiratory infections by molecular tools and in vitro antifungal susceptibilities by using broth microdilution method according to CLSI M27-A3 guidelines. Totally, 121 respiratory samples were collected from patients with respiratory infections. Of these, 83 strains were germ tube positive and green colonies on chromogenic media, so initially identified as C.albicans species complex and subsequently were classified as C.albicans (89.15%), C.dubliniensis (9.63%), and C.africana (1.2%) based on PCR-RFLP and amplification of hwp1 gene. Minimum inhibitory concentration (MICs) results showed that all tested isolates of C.albicans complex were highly susceptible to triazole drugs. However, caspofungin had highest activity against C.albicans , C.dubliniensis , and C.africana . Our findings indicated the variety of antifungal resistance of Candida strains in different areas. These results may increase the knowledge about the local distribution of the mentioned strains as well as their antifungal susceptibility pattern which play an important role in appropriate therapy.
کلیدواژه‌های انگلیسی مقاله In vitro susceptibility,C.albicans complex,Caspofungin
نویسندگان مقاله سمیه شریفی نیا | somayeh sharifynia
department of medical mycology and parasitology, school of public health, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

حمید بدلی | hamid badali
department of medical mycology and parasitology, pharmaceutical sciences research center, school of medicine, mazandaran university of medical sciences, sari, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

مینا شریفی sorkherizi | mina sharifi sorkherizi
department of medical mycology and parasitology, school of public health, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

محمد رضا شیدفر | mohammad reza shidfar
department of medical mycology and parasitology, school of public health, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

عاطفه هادیان | atefe hadian
department of medical mycology and parasitology, school of public health, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

شادی شاهرخی | shadi shahrokhi
islamic azad university, varamin-pishva branch, varamin, iran.

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

غزاله قندچی | ghazale ghandchi
pediatric infections research center, shahid beheshti university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

ساسان رضایی | sassan rezaie
department of medical mycology and parasitology, school of public health, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/4996
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