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Acta Medica Iranica، جلد ۵۴، شماره ۴، صفحات ۲۳۳-۲۳۹
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عنوان انگلیسی Synergistic Effect of Honey and Propolis on Cutaneous Wound Healing in Rats
چکیده انگلیسی مقاله Accelerating wound healing is now considered as a principle clinical treatment and increasing the quality and speed of healing which has always been emphasized by the scientists. Propolis and honey are natural bee products with wide range of biological and medicinal properties. This study was aimed to determine the synergistic effect of honey and propolis in wound healing of rat skin. A total of 75 Wistar rats weighing 200-250 gr were placed under general anesthesia and sterile conditions. Then a square shape wound with 1.5*1.5 mm dimension was made on the back of the neck. Animals were randomly divided into control, honey, propolis, combined honey propolis and phenytoin 1% groups, respectively. Rats were randomly divided into the following groups: 4th, 7th and, 14th days of treatment in each period of study. Wound area in the experimental group was covered once daily with a fixed amount of thyme honey, propolis, propolis and honey and phenytoin cream (1%), the control group did not receive any treatment. For histological studies, during the fourth, seventh and fourteenth day’s rats were sacrificed and samples were taken from the wound and adjacent skin. After histological staining fibroblast, neutrophils, macrophages and vascular sections were counted in the wound bed. The macroscopic and microscopic evaluations showed that the percentage of wound healing on different days in the experimental and control groups were significant ( P < 0.05). The macroscopic and microscopic evaluation showed that the percentage of wound healing on different days in combined propolis and honey experimental group was significantly different from the control group (Multivariate ANOVA test) ( P < 0.05). Combined application of propolis and honey on the open wound healing in rats has a synergistic effect.
کلیدواژه‌های انگلیسی مقاله Open cutaneous wound,Healing,Honey,Propolis,Synergism,Rats
نویسندگان مقاله نسرین تک زارع | nasrin takzaree
department of anatomy and medicinal plants research center, school of medicine, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

عباس حاجی آخوندی | abbas hadjiakhondi
department of pharmacognosy and medicinal plants research center, school of pharmacy, tehran university of medical sciences, tehran, iran,

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

غلامرضا حسن زاده | gholamreza hassanzadeh
department of anatomy, school of medicine, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

محمد رضا رویینی | mohammad reza rouini
department of pharmaceutics, school of pharmacy, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

آزاده منایی | azadeh manayi
medicinal plants research center, school of pharmacy, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/5023
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article(s)
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