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Acta Medica Iranica، جلد ۵۴، شماره ۳، صفحات ۱۶۵-۱۷۲
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عنوان انگلیسی Effect of Withania somnifera Dunal Root Extract on Behavioral Despair Model in Mice: a Possible Role for Nitric Oxide
چکیده انگلیسی مقاله Withania somnifera (WS) possess anti-inflammatory and antioxidant properties. WS preparations have a potential therapeutic role in the central nervous system (CNS) related disorders in animal models. In this study, the possible protective effect of acute aqueous WS root extract on behavioral despair was explored and compared with fluoxetine, an antidepressant with selective serotonin (5-HT) reuptake inhibitor activity (SSRI). Further, the probable involvement of nitric oxide (NO) determined to measure immobility time in forced swimming test (FST) and tail suspension test (TST) in male mice. Immediately after assessment of locomotor activity, the immobility time was evaluated. WS was administered intraperitoneally (200, 400 mg/kg; i.p. ) 60 min before the behavioral tests. To assess the involvement of NO in the possible protective effect of WS, a non-specific NO synthase inhibitor, NG-L-arginine methyl ester (L-NAME, 10 mg/kg, i.p. ) was administered 30 min before the extract administration (400 mg/kg, i.p. ), 90 min before the tests. Acute WS extract (200, 400 mg/kg, i.p. ) dose-dependently decreased the immobility time in FST, P < 0.05, P < 0.001, respectively and 400 mg/kg proved the most effective dose and this dose was comparable to fluoxetine (20 mg/kg, i.p. WS (400 mg/kg, i.p. ) also lowered the immobility measure in TST ( P < 0.05). However, these effects were not related to change in locomotor activity. Moreover, L-NAME (10 mg/kg, i.p. ) did not influence the effect of the extract on the behavioral tests. As a consequence, the immobility time was virtually constant between the group received the extract (400 mg/kg) alone, and the group received L-NAME (10 mg/kg) before the extract. It is probable that NO does not mediate this beneficial effect, and WS may affect other neurochemical systems and pathways.
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نویسندگان مقاله مهشید عطاری | mahshid attari
department of biology, islamic azad university, qom branch, qom, iran. and brain and spinal cord injury research center, neuroscience institute, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

فاطمه jamaloo | fatemeh jamaloo
department of biology, islamic azad university, qom branch, qom, iran.

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

سحر شادور | sahar shadvar
brain and spinal cord injury research center, neuroscience institute, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

ناهید فخرایی | nahid fakhraei
brain and spinal cord injury research center, neuroscience institute, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

احمد رضا دهپور | ahmad reza dehpour
brain and spinal cord injury research center, neuroscience institute, tehran university of medical sciences, tehran, iran. and experimental medicine research center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/5549
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