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Research in Pharmaceutical Sciences، جلد ۱۸، شماره ۶، صفحات ۵۹۲-۶۰۳
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Andrographis paniculata extract versus placebo in the treatment of COVID-19: a double-blinded randomized control trial
چکیده انگلیسی مقاله Background and p urpose: Andrographis paniculata (Burm.f.) Nees has been recommended to relieve symptoms and decrease the severity of COVID-19. The clinical study aimed to investigate the efficacy and safety of A . paniculata ethanolic extract (APE). Experimental approach: The efficacy and safety of APE in asymptomatic or mildly symptomatic COVID-19 patients compared with placebo were investigated through a prospective, double-blind randomized control trial. Patients received APE containing 60 mg of andrographolide, three times a day for five days. WHO progression scale, COVID-19 symptoms, and global assessment evaluated the efficacy and adverse events, liver and renal functions were monitored for safety. Findings/Results: 165 patients completed the study (83 patients in the APE group and 82 patients in the placebo group). The highest WHO progression scale was 4 and COVID-19 symptoms were significantly relieved on the last day of intervention in both groups, with no significant difference between groups. APE significantly relieved headache symptoms on day 1 and olfactory loss symptoms on day 2 compared to placebo. The global assessment showed that 80.7% of patients had total recovery after 5-day treatment with APE. Mild diarrhea was the most common side effect with a high dose that resolved within a few days. No hepatic or renal toxicity was associated with treatment. Conclusion and i mplications : APE at 180 mg/day for 5 days did not reduce COVID-19 progression in asymptomatic or mildly afflicted COVID-19 patients, however, it shortened the symptoms of olfactory loss with no adverse effects over 5 days of use.
کلیدواژه‌های انگلیسی مقاله Capsule,Clinical trial,Coronavirus, HPLC.
نویسندگان مقاله | Puritat Kanokkangsadal
Department of Surgery, Faculty of Medicine, Thammasat University, Pathumtani 12120, Thailand.


| Chatchai Mingmalairak
Department of Applied Thai Traditional Medicine, Faculty of Medicine, Thammasat University, Pathumthani 12120, Thailand. Center of Excellence on Applied Thai Traditional Medicine Research (CEATMR), Faculty of Medicine, Thammasat University, Klong Luang, Pathumthani 12120, Thailand.


| Nichamon Mukkasombat
Center of Excellence on Applied Thai Traditional Medicine Research (CEATMR), Faculty of Medicine, Thammasat University, Klong Luang, Pathumthani 12120, Thailand.


| Pranporn Kuropakornpong
Department of Applied Thai Traditional Medicine, Faculty of Allied Health Science, Burapha University, Chonburi, 20131, Thailand.


| Patsorn Worawattananutai
Department of Internal Medicine, Faculty of Medicine, Thammasat University, Pathumtani 12120, Thailand.


| Thana Khawcharoenporn
Department of Applied Thai Traditional Medicine, Faculty of Medicine, Thammasat University, Pathumthani 12120, Thailand.


| Intouch Sakpakdeejaroen
Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2P5, Canada.


| Neal M. Davies
Department of Applied Thai Traditional Medicine, Faculty of Medicine, Thammasat University, Pathumthani 12120, Thailand. Center of Excellence on Applied Thai Traditional Medicine Research (CEATMR), Faculty of Medicine, Thammasat University, Klong Luang, Pathumthani 12120, Thailand.


| Arunporn Itharat


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/2215
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