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Research in Pharmaceutical Sciences، جلد ۱۸، شماره ۶، صفحات ۶۹۶-۷۰۷
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عنوان انگلیسی Moderate exercise mitigates cardiac dysfunction and injury induced by cyclosporine A through activation of the PGI2 / PPAR-γ signaling pathway
چکیده انگلیسی مقاله Background and purpose: The present study investigated the role of the prostaglandin I 2 /peroxisome proliferator activator receptor (PGI 2 /PPAR) signaling pathway in cardiac cell proliferation, apoptosis, and systemic hemodynamic variables under cyclosporine A (CsA) exposure alone or combined with moderate exercises. Experimental approach: Twenty-four male Wistar rats were classified into three groups, namely, control, CsA, and CsA + exercise. Findings/Results: After 42 days of treatment, the findings showed a significant enhancement in the expression of the β-MHC gene, enhancement in protein expression of Bax and caspase-3, and a significant decline in the protein expression of Bcl-2 expression, as well as increased proliferation intensity in the heart tissue of the CsA group compared to the control group. Systolic pressure, pulse pressure, mean arterial pressure (MAP), QT and QRS duration, and T wave amplitude, as well as QTc amount in the CsA group, showed a significant increase compared to the control group. PPAR-γ and PGI 2 showed no significant changes compared to the control group. Moderate exercise along with CsA significantly enhanced the protein expression of PPAR-γ and PGI 2 and declined protein expression of Bax, and caspase-3 compared to those in the CsA group. In the CsA + exercise group, systolic pressure, MAP, and T wave showed a significant decrease compared to the CsA group. Moderate exercises along CsA improved heart cell proliferation intensity and significantly reduced        β-MHC gene expression compared to the CsA group. Conclusions and implications: The results showed moderate exercise alleviated CsA-induced heart tissue apoptosis and proliferation with the corresponding activation of the PGI 2 /PPAR-γ pathway.
کلیدواژه‌های انگلیسی مقاله Cyclosporine,Exercise,Heart,PGI2/PPAR signaling pathway,Proliferation.
نویسندگان مقاله | Khatereh Nourmohammadi
Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, Ardabil, Iran.


| Abolfazl Bayrami
Department of Physiology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran. Nephrology and Kidney Transplant Research Center, Clinical Research Institute, Urmia University of Medical Sciences, Urmia, Iran.


| Roya Naderi
Department of Physiology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran. Nephrology and Kidney Transplant Research Center, Clinical Research Institute, Urmia University of Medical Sciences, Urmia, Iran.


| Alireza Shirpoor
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran.


| Hamid Soraya


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/2224
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