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Avicenna Journal of Phytomedicine، جلد ۱۴، شماره ۱، صفحات ۵۰-۶۳
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عنوان انگلیسی Naringin mitigates testicular injury and associated neuronal toxicity in lead-exposed cockerel chicks
چکیده انگلیسی مقاله Objective: Lead (Pb) poisoning affects multiple organs including the reproductive system. The experiment was performed to explore the protective effect of naringin on testicular apoptosis, neuronal dysfunction and markers of stress in cockerel chicks.Materials and Methods: Thirty-six cockerel chicks were used for this study, and randomly grouped into six chicks per group viz. control, Pb only (600 ppm), Pb and naringin (80 mg/kg), Pb and Naringin (160 mg/kg), naringin only (80 mg/kg) and naringin only (160 mg/kg), respectively, for eight weeks. Pb was administered via drinking water while naringin was administered via oral gavage. Oxidative stress indices in the brain and testes were assessed, and immunohistochemistry of TNF-α and caspase 3 was done in the brain and testes, respectively.Results: Lead administration induced inflammatory and testicular apoptosis cascade accompanied with increased oxidative stress and upregulation of brain and testicular antioxidant enzymes in comparison to the control and Pb-only-treated cockerels. Immunohistochemistry showed significant immunoreactivity of testicular caspase 3 and TNF-α in the brain.Conclusion: Treatment of Pb-exposed chickens with naringin offered protection to Pb acetate-induced testicular oxidative stress, apoptosis, and neuroinflammation in cockerel chicks.
کلیدواژه‌های انگلیسی مقاله Lead toxicity, Oxidative stress, Testicular apoptosis, Neuroinflammation
نویسندگان مقاله | Oluwaseun Esan
Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Ibadan, Nigeria


| Chinomso Ebirim
Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Ibadan, Nigeria


| Moses Olusola Adetona
Department of Anatomy, Faculty of Basic Medical Sciences, University of Ibadan, Nigeria


| Temitayo Ajibade
Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Ibadan, Nigeria


| Ademola Adetokunbo Oyagbemi
Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Ibadan, Nigeria


| Temidayo Omobowale
Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Ibadan, Nigeria


| Omolade Abodunrin Oladele
Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Ibadan, Nigeria


| Adeolu Adedapo
Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Ibadan, Nigeria


| Momoh Yakubu
Department of Environmental & Interdisciplinary Sciences, College of Science, Engineering & Technology, COPHS, Texas Southern University, Houston, TX, USA


| Evaristus Nwulia
Howard University, College of Medicine, Department of Psychiatry and Behavioral Sciences, Howard University Hospital, 2041 Georgia Avenue, Washington, DC 20060, USA


| Oluwafemi Oguntibeju
Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Bellville 7535, South Africa
نشانی اینترنتی https://ajp.mums.ac.ir/article_22946.html
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