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Acta Medica Iranica، جلد ۵۳، شماره ۱۲، صفحات ۷۷۰-۷۷۷
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عنوان انگلیسی The Intricate Expression of CC Chemokines in Glial Tumors: Evidence for Involvement of CCL2 and CCL5 but Not CCL11
چکیده انگلیسی مقاله Chemokines are biologically active peptides involved in the pathogenesis of various pathologies including brain malignancies. They are amongst primitive regulators of the development of immune responses against malignant glial tumors. The present study aimed to examine the expression of CC chemokines in anaplastic astrocytoma and glioblastoma multiform patients at both mRNA and protein levels. Blood specimens in parallel with stereotactic biopsy specimens were obtained from 123 patients suffering from glial tumors and 100 healthy participants as a control. The serum levels of CCL2, CCL5, and CCL11 were measured by ELISA and stereotactic samples subjected to western and northern blotting methods for protein and mRNA, respectively. Demographic characteristics were also collected by a researcher-designed questionnaire. Results of the present study indicated that, however,CCL2 andCCL5 are elevated in serum and tumor tissues of patients suffering from a glial tumor at both mRNA and protein levels, theCCL11 was almost undetectable. According to the findings of the present investigation, it could presumably be reasonable to conclude that chemokines are good predictive molecules for expecting disease severity, metastasis, and response to treatment.
کلیدواژه‌های انگلیسی مقاله Glioblastoma,Anaplastic astrocytoma,Chemokine
نویسندگان مقاله مژگان موگویی | mozhgan moogooei
department of immunology, rafsanjan university of medical sciences, rafsanjan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی رفسنجان (Rafsanjan university of medical sciences)

مسعود شماعی | masoud shamaei
pediatric respiratory diseases research center, national research institute of tuberculosis and lung diseases nritld , shahid beheshti university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

حسین خرم دل آزاد | hossein khorramdelazad
molecular medicine research center, rafsanjan university of medical sciences, rafsanjan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی رفسنجان (Rafsanjan university of medical sciences)

شیرین فتاح پور | shirin fattahpour
department of biochemistry, rafsanjan university of medical sciences, rafsanjan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی رفسنجان (Rafsanjan university of medical sciences)

سید محمد سیدمهدی | seyed mohammad seyedmehdi
pediatric respiratory diseases research center, national research institute of tuberculosis and lung diseases nritld , shahid beheshti university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

مریم موگویی | maryam moogooei
department of immunology, shahid sadoughi university of medical sciences and health services, yazd, iran


غلامحسین حسن شاهی | gholamhossein hassanshahi
molecular medicine research center, rafsanjan university of medical sciences, rafsanjan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی رفسنجان (Rafsanjan university of medical sciences)

بهجت کلانتری خاندانی | behjat kalantari khandani
department of internal medicine, school of medicine, kerman university of medical sciences, kerman, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/5296
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زبان مقاله منتشر شده en
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