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Basic and Clinical Neuroscience، جلد ۱۴، شماره ۶، صفحات ۰-۰
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی Co-Exposure to Toluene and Noise Made Synergistic and Antagonistic Effects on Some Neurotoxic Parameters in New Zealand White Rabbits
چکیده انگلیسی مقاله
Introduction: Numerous physical and chemical agents can induce destructive effects on the brain tissue. Noise and toluene, which are some of these harmful agents, have significant adverse effects on the brain tissue. This work aims to investigate the neurotoxic changes induced by co-exposure to toluene and noise.
Methods: Totally, 24 male white New Zealand rabbits were randomly segregated into 4 groups including toluene exposure, noise exposure, co-exposure to noise and toluene, and control. This in-vivo study tested the neurotoxic effects of exposure to 1000 ppm toluene and 100 dB noise during two weeks (8 h/day). The serum levels of brain-derived neurotrophic factor-α (BDNF-α) and malondialdehyde (MDA), total antioxidant capacity (TAC), glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase levels in the brain tissue were measured. Moreover, hematoxylin and eosin staining was utilized for brain pathological analysis.
Results: Exposure to noise increased TAC level in the cerebral cortex. Co- exposure to toluene and noise increased the serum level of BDNF-α. Nevertheless, exposure to noise decreased the level of BDNF-α in serum. On the other hand, hispathological examinations using hematoxylin-eosin (H&E) exhibited that different signs of inflammation such as lymphocyte infiltration, pyknosis, vacuolization, and chromatolysis were induced by exposure to noise and toluene in the cerebellum, hippocampus, and frontal section in the brain tissue. In addition, simultaneous exposure to toluene and noise induced antagonistic and synergistic changes on some neurotoxic parameters.
Conclusion: Exposure to noise and toluene, which caused inflammation in the brain tissue cells, could be a noticeable risk factor for neurological system.
کلیدواژه‌های انگلیسی مقاله Noise, Toluene, Brain, Neurotoxicity, Oxidative stress
نویسندگان مقاله | Amirreza Abouee-Mehrizi
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.


| Masoud Motalebi Kashani
Occupational Health & Safety Department, Kashan University of Medical Sciences, Kashan, Iran.


| Yahya Rasoulzadeh
Department of Occupational Health Engineering, Tabriz University of Medical Sciences, Tabriz, Iran.


| Ahmad Mehdipour
Department of Tissue Engineering, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.


| Nafiseh Nasirzadeh
Department of Occupational Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.


| Omid Shatouei-Gharenjeh
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.


| Abbas Ebrahimi-Kalan
Neurosciences Research Center (NRC), Department of Neurosciences and Cognitive, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
نشانی اینترنتی http://bcn.iums.ac.ir/browse.php?a_code=A-10-3301-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Cellular and molecular Neuroscience
نوع مقاله منتشر شده Original
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