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Acta Medica Iranica، جلد ۵۳، شماره ۷، صفحات ۳۹۵-۴۰۲
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عنوان انگلیسی Elevated Serum Levels of Pregnancy-Associated Plasma Protein-A in Type 2 Diabetics Compared to Healthy Controls: Associations with Subclinical Atherosclerosis Parameters
چکیده انگلیسی مقاله Type 2 diabetes mellitus is associated with increased inflammation and accelerated atherosclerosis. The association of the pro-inflammatory and potentially pro-atherosclerotic molecule, pregnancy associated plasma protein-A (PAPP-A) with diabetes and vascular diseases remains to be further established. A total of 107 patients with type 2 diabetes and 101 healthy controls participated in this study. Serum levels of PAPP-A was measured by Enzyme-linked Immunosorbent Assay (ELISA). We also evaluated the lipid profile, aortic augmentation index, coronary calcium score, ankle brachial index, flow mediated dilation, and carotid intima media thickness. Serum level of PAPP-A was significantly higher in patients with diabetes compared to controls ( P PP=0.021) and was negatively associated with coronary calcification ( P =0.050). In conclusion, serum levels of PAPP-A were significantly higher in diabetics compared to healthy controls and correlated with aortic augmentation index and coronary calcification. Our study results suggest that PAPP-A can be a marker of subclinical atherosclerosis in patients with diabetes.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله بهنام حیدری | behnam heidari
elderly health research center, endocrinology and metabolism population sciences institute, tehran university of medical sciences, tehran, iran and endocrinology and metabolism research center, vali-asr hospital, school of medicine, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

اکبر فتوحی | akbar fotouhi
department of epidemiology and biostatistics, school of public health, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

frshad شریفی | frshad sharifi
elderly health research center, endocrinology and metabolism population sciences institute, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

کاظم محمد | kazem mohammad
department of epidemiology and biostatistics, school of public health, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

محمد پژوهی | mohammad pajouhi
endocrinology and metabolism research center, endocrinology and metabolism clinical sciences institute, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

کوشا paydary | koosha paydary
iranian research center for hiv aids ircha , iranian institute for reduction of high-risk behaviors, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

حسین فخرزاده | hossein fakhrzadeh
elderly health research center, endocrinology and metabolism population sciences institute, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/4267
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article(s)
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