این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Acta Medica Iranica، جلد ۵۲، شماره ۱۱، صفحات ۸۱۱-۸۱۵
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Polymorphism of interleukin 6 -174 G/C in Behcet disease: case series and review of literature.
چکیده انگلیسی مقاله To assess the association between polymorphisms of the IL-6 -174 G/C and Behçet's disease (BD) in Tunisian patients. DNA was extracted from blood samples taken from 43 Tunisian patients and 43 healthy controls. The polymorphisms were analyzed by PCR with the PCR-RFLP. No significant association was found between patients and controls concerning polymorphism of IL6 -174 G/C between the (allelic frequency: C (17.44 vs 8, 13%; P=0.17) et G (82,55 vs 91,86%; P= 0.21). Neither age of onset of BD nor sex appears to be influenced by allelic variation of SNP-174 G / C of IL6. Disease duration of BD was longer in patients having the form 174 G-allele. SNP -174G/C was more frequent in patients without significant association (32.5 vs 16,26% ; P=0.07). SNP -174 G/C was not associated with the HLA B51. Neither age of onset of BD nor sex appears to be influenced by SNP-174 G / C of IL6. Disease duration of BD was longer in the absence of the SNP-174 G/C IL6, with no significant difference (79.2 + / -45.095 vs.70.28 + / - 47.034 months, P=0.59). The polymorphism of IL6 -174 G/C does not modulate clinical expression of BD. The single nucleotide polymorphisms of the IL-6 do not appear to be associated with BD reconstruction.
کلیدواژه‌های انگلیسی مقاله Behcet disease,IL 6,Polymorphism IL6
نویسندگان مقاله کاظمی پور hamzaoui | amira hamzaoui
department of internal medicine, fattouma bourguiba hospital, monastir, tunisia.


rim klii | rim klii
department of internal medicine, fattouma bourguiba hospital, monastir, tunisia.


olfa harzallah | olfa harzallah
department of internal medicine, fattouma bourguiba hospital, monastir, tunisia.


touhami محجوب | touhami mahjoub
department of internal medicine, fattouma bourguiba hospital, monastir, tunisia.


سیلویا محجوب | silvia mahjoub
department of genetic, university of pharmacology, monastir, tunisia.
نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/4542
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Articles
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات