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Iranian Journal of Basic Medical Sciences، جلد ۲۷، شماره ۲، صفحات ۲۲۳-۲۳۲
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عنوان انگلیسی Fabrication and evaluation of the regenerative effect of a polycaprolactone/chitosan nanofibrous scaffold containing bentonite nanoparticles in a rat model of deep second-degree burn injury
چکیده انگلیسی مقاله Objective(s): In the present study, we evaluated the effect of a nanofibrous scaffold including polycaprolactone (PCL), chitosan (CHT), and bentonite nanoparticles (Ben-NPS) on wound healing in order to introduce a novel dressing for burn wounds. Materials and Methods: PCL, PCL/CHT, and PCL/CHT/Ben-NPS nanofibrous scaffolds were fabricated by the electrospinning technique. Their structural and physiochemical characteristics were investigated by Fourier-transform infrared spectroscopy (FTIR) analysis, scanning electron microscopy (SEM), tensile strength, water contact angle, as well as, swelling and degradation profiles test. The disc diffusion assay was carried out to investigate the antibacterial potential of the scaffolds. In addition, the cell viability and proliferation ability of human dermal fibroblasts (HDFs) on the scaffolds were assessed using MTT assay as well as SEM imaging. The wound-healing property of the nanofibrous scaffolds was evaluated by histopathological investigations during 3,7, and 14 days in a rat model of burn wounds. Results: SEM showed that all scaffolds had three-dimensional, beadles-integrated structures. Adding Ben-NPS into the PCL/CHT polymeric composite significantly enhanced the mechanical, swelling, and antibacterial properties. HDFs had the most cell viability and proliferation values on the PCL/CHT/Ben-NPS scaffold. Histopathological evaluation in the rat model revealed that dressing animal wounds with the PCL/CHT/Ben-NPS scaffold promotes wound healing. Conclusion: The PCL/CHT/Ben-NPS scaffold has promising regenerative properties for accelerating skin wound healing.
کلیدواژه‌های انگلیسی مقاله Bentonite-nanoparticles, Nanofibrous scaffold, Polycaprolactone, Rat, Wound healing
نویسندگان مقاله | Seyedeh Sara Hashemi
Burn and Wound Healing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran


| Ali-Akbar Mohammadi
Burn and Wound Healing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran|Division of Plastic and Reconstructive Surgery, Department of Surgery, Shiraz University of Medical Sciences, Shiraz, Fars, Iran


| Mehdi Kian
Department of Comparative Biomedical Sciences, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Fars, Iran|Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Fars, Iran


| Alireza Rafati
Division of Pharmacology and Pharmaceutical Chemistry, Sarvestan Branch, Islamic Azad University, Sarvestan, Fars, Iran


| Mojtaba Ghaedi
Department of Surgery, School of Medicine, Jahrom University of Medical Sciences, Jahrom, Fars, Iran


| Behzad Ghafari
Division of Plastic and Reconstructive Surgery, Department of Surgery, Shiraz University of Medical Sciences, Shiraz, Fars, Iran
نشانی اینترنتی https://ijbms.mums.ac.ir/article_23226.html
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