این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Middle East Journal of Cancer، جلد ۱۵، شماره ۱، صفحات ۵۲-۶۱
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Feasibility of Dose Reduction to the Left Anterior Descending Coronary Artery without Compromising Target Volume Coverage Using Tomotherapy Techniques
چکیده انگلیسی مقاله Background: Radiotherapy is associated with a high risk of heart disease in patients with left-sided breast cancer. Previously, the entire heart was considered an organ at risk (OAR) during planning. Studies have shown that the effect of radiation therapy depends on the dose to specific heart substructures. However, the tolerance dose of the left anterior descending coronary artery (LAD), an important cardiac substructure, is yet to be determined. This study aims to verify the feasibility of reducing the LAD dose with appropriate dose-volume constraints for patients undergoing left whole-breast radiotherapy, without compromising the target dose coverage, using tomotherapy techniques.
Method: This retrospective study generated tomohelical and tomodirect plans initially without considering the LAD as OAR in the treatment planning. To reduce the LAD dose, plans were regenerated by including the LAD as an OAR with appropriate dose constraints. The dose-volume histogram parameters of these plans were compared with those of the initial plans of the respective types.
Results: Tomohelical plans showed a 4.4% reduction in maximum dose and a 3.8% reduction in V15 for LAD, while tomodirect plans registered a 3% reduction in V15, with the conformity index remaining constant. Based on the LAD dosimetric results, considering the LAD as an OAR is associated with lower LAD doses without compromising the target volume coverage.
Conclusion: It is feasible to reduce the LAD dose without compromising target volume coverage or affecting other OAR doses in patients with left breast cancer, using tomotherapy techniques.
کلیدواژه‌های انگلیسی مقاله Heart diseases, Tomotherapy, Helical, Left-sided breast cancer, Coronary artery, LAD Dose reduction
نویسندگان مقاله Lakshmi Venkataramana Puriparthi |
Department of Radiation Physics, Basavatarakam Indo American Cancer Hospital and Research Institute, Hyderabad, India

Akkineni Naga Prasanthi |
Department of Radiation Oncology, Basavatarakam Indo American Cancer Hospital and Research Institute, Hyderabad, India

Anil Kumar Talluri |
Department of Radiation Physics, Basavatarakam Indo American Cancer Hospital and Research Institute, Hyderabad, India

Venkatappa Rao Tumu |
Department of Physics, National Institute of Technology, Warangal, Telangana, India

Nagarjuna Reddy Bomidika |
Department of Radiation Oncology, Basavatarakam Indo American Cancer Hospital and Research Institute, Hyderabad, India

Madhusudhana Sresty |
Department of Radiation Physics, Basavatarakam Indo American Cancer Hospital and Research Institute, Hyderabad, India

Krishnam Raju Alluri |
Department of Radiation Oncology, Basavatarakam Indo American Cancer Hospital and Research Institute, Hyderabad, India

نشانی اینترنتی https://mejc.sums.ac.ir/article_49312_7dbec477f3929ebf5591d336d32e4e59.pdf
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات