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Iranian Journal of Public Health، جلد ۵۳، شماره ۱، صفحات ۲۰۸-۲۱۸
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عنوان انگلیسی MiR-103a-3p Promotes Tumorigenesis of Breast Cancer by
چکیده انگلیسی مقاله Background: We aimed to elucidate the molecular mechanism of miR-103a-3p regulating breast cancer progression. Methods: Firstly, clinical tissues was obtained from 2019-2023 at Yancheng Third People's Hospital, Yancheng, China. miR-103a-3p or ETNK1 expression in clinical tissues or breast cancer cell lines was analyzed with qRT-PCR. MDA-MB-231 cells were performed with miR-103a-3p inhibitor or mimic, and OE-ETNK1. The proliferation and apoptosis ability were detected by CCK-8 and TUNEL assay. The xenograft models were established by inoculating transfected MDA-MB-231 cells to BALB/c mice. Results: miR-103a-3p showed an overexpression and was related to poor prognosis in breast cancer. miR-103a-3p-deprived MDA-MB-231 cells displayed weaker levels of cell proliferation and higher rates of apoptosis. In contrast, ETNK1 was downregulated in breast cancer and proved to be a downstream target of miR-103a-3p. Xenograft models subjected to either miR-103a-3p antagomir treatment or ETNK1-knockdown resulted in tumor growth suppression. Conclusion: miR-103a-3p might promote breast cancer progression by inhibiting ETNK1.Breast cancer
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نویسندگان مقاله | Yuhua Shi
Department of General Surgery, The Sixth Affiliated Hospital of Nantong University, Yancheng Third People's Hospital, Yancheng, 224000, China


| Lei Li
Department of General Surgery, The Sixth Affiliated Hospital of Nantong University, Yancheng Third People's Hospital, Yancheng, 224000, China


| Aifeng Qiu
Department of General Surgery, The Sixth Affiliated Hospital of Nantong University, Yancheng Third People's Hospital, Yancheng, 224000, China
نشانی اینترنتی https://ijph.tums.ac.ir/index.php/ijph/article/view/32066
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