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Acta Medica Iranica، جلد ۵۲، شماره ۵، صفحات ۳۵۲-۳۵۹

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عنوان انگلیسی Association of polymorphisms at LDLR locus with coronary artery disease independently from lipid profile.
چکیده انگلیسی مقاله Coronary artery disease (CAD) is the leading cause of mortality in many parts of the world. Genome-wide association studies (GWAS) have identified several genetic variants associated with CAD in Low-density lipoprotein receptor (LDLR) locus. This study was evaluated the possible association of genetic markers at LDLR locus with CAD irrespective to lipid profile and as well as the association of these SNPs with severity of CAD in Iranian population. Sequencing of 2 exons in LDLR gene (Exon 2, 12) and part of intron 30 of SMARCA4 gene include rs1122608, was performed in 170 Iranian patients angiographically confirmed CAD and 104 healthy controls by direct sequencing. Sullivan's scoring system was used for determining the severity of CAD in cases. Our results showed that homozygote genotypes of rs1122608 (P< 0.0001), rs4300767 (P< 0.005) and rs10417578 (p< 0.007) SNPs have strong protective effects on the CAD. In addition, we found that rs1122608 (GT or TT) was at higher risk of three vessel involvement compared to single vessels affecting (P=0.01).
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نویسندگان مقاله سید حمید جمالدینی | seyed hamid jamaldini
department of genetics, genetic research center, university of social welfare and rehabilitation sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم بهزیستی و توانبخشی (University of social welfare and rehabilitation sciences)

مژگان بابانژاد | mojgan babanejad
department of genetics, genetic research center, university of social welfare and rehabilitation sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم بهزیستی و توانبخشی (University of social welfare and rehabilitation sciences)

رضا مظفری | reza mozaffari
department of genetics, cardiogenetic research center, tehran, iran-department of genetics, shahid rajaie cardiovascular medical amp;amp; research center, tehran, iran.


نوشین نیک ذات | nooshin nikzat
department of genetics, genetic research center, university of social welfare and rehabilitation sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم بهزیستی و توانبخشی (University of social welfare and rehabilitation sciences)

خدیجه جلالوند | khadijeh jalalvand
department of genetics, genetic research center, university of social welfare and rehabilitation sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم بهزیستی و توانبخشی (University of social welfare and rehabilitation sciences)

آزاده بدیعی | azadeh badiei
department of genetics, genetic research center, university of social welfare and rehabilitation sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم بهزیستی و توانبخشی (University of social welfare and rehabilitation sciences)

حمیدرضا صنعتی | hamidreza sanati
department of genetics, cardiogenetic research center, tehran, iran-department of genetics, shahid rajaie cardiovascular medical amp;amp; research center, tehran, iran.


فرشاد شاکریان | farshad shakerian
department of genetics, cardiogenetic research center, tehran, iran-department of genetics, shahid rajaie cardiovascular medical amp;amp; research center, tehran, iran.


مهدی افشاری | mahdi afshari
department of health, faculty of health, zabol university of medical science, zabol, iran.

سازمان اصلی تایید شده: دانشگاه زابل (Zabol university)

کیمیا کهریزی | kimia kahrizi
department of genetics, genetic research center, university of social welfare and rehabilitation sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم بهزیستی و توانبخشی (University of social welfare and rehabilitation sciences)

دکتر حسین نجم آبادی | hossein najmabadi
department of genetics, genetic research center, university of social welfare and rehabilitation sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم بهزیستی و توانبخشی (University of social welfare and rehabilitation sciences)


نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/4618
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