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Iranian Journal of Pediatric Hematology and Oncology، جلد ۱۴، شماره ۱، صفحات ۱-۱۶
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عنوان انگلیسی The Epidemiological Study of Children with Malignant Disorders in the Pediatric Department at Menoufia University Hospital, Menoufia, Egypt during the Last Fifteen Years
چکیده انگلیسی مقاله
Background: This study aims to assess the epidemiological, clinical, and paraclinical characteristics and survival of childhood with malignant disorders in the pediatrics department, menoufia University Hospital.
Methods: A retrospective study with clinical and epidemiological data from patients was conducted on 314 children who attended Pediatric Department, Haematology-Oncology Unit, Menoufia University Hospital during the last fifteen years.
Results: 314 children were assessed, their ages ranged from 2 months-18 years with mean 5.96±3.79 years. Also, 252 (80.3%) were diagnosed with hematological malignancies, and 62 (19.5%) were diagnosed with solid tumors. Among hematological malignancies, 186 were diagnosed with acute leukemia, 158 (49.7%) with acute lymphoblastic leukemia (ALL), and 28 (8.8%) with acute myeloid leukemia (AML). The most frequent clinical presentations were fever in 95.24% in hematological malignancies vs 48.4% in solid (p<0.001),, pallor in 92.5% in hematological malignancies vs 69.4% in solid (p<0.001), hepatomegaly in 81.3% in hematological malignancies vs 37.1% in solid (p<0.001),, lymphadenopathy in 77.6 % in hematological malignancies vs 24.2% in solid (p<0.001), and splenomegaly in 76.3% of hematological malignancies vs 12.9% in solid (p<0.001),The majority of the patients 64.15% had white blood cells (WBCs) less than 50,000/mm³, while 35.85% had WBCs more or equal to 50,000/mm³ with significant relation with risk stratification (p=0.001). The survivors who finished their treatment course were 31.8% and the recurence patients were 9%.
Conclusion: Acute lymphoblastic leukemia is the most frequent childhood hematological neoplasm. Various clinical and laboratory features present at the time of initial diagnosis can predict the likelihood that a patient will remain in remission or not including age: under 1 and over 10 years, gender: male sex, WBCS more than 50,000/mm³ at presentation.
کلیدواژه‌های انگلیسی مقاله Acute lymphoblastic leukemia, Cancer, Children, Epidemiology, Malignant disorders
نویسندگان مقاله | Seham M. Ragab
Pediatrics department, Faculty of Medicine, Menoufia University, Shebin El Kom, Egypt


| Mahmoud A. El-Hawy
Pediatrics department, Faculty of Medicine, Menoufia University, Shebin El Kom, Egypt


| Asmaa A. Mahmoud
Pediatrics department, Faculty of Medicine, Menoufia University, Shebin El Kom, Egypt


| Aliaa Rabie Bayomi
Pediatrics department, Faculty of Medicine, Menoufia University, Shebin El Kom, Egypt


| Mai El-Sayad Abd El-Hamid
Pediatrics department, Faculty of Medicine, Menoufia University, Shebin El Kom, Egypt
نشانی اینترنتی http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-1052-1&slc_lang=en&sid=1
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