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Acta Medica Iranica، جلد ۵۲، شماره ۲، صفحات ۹۴-۱۰۰
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عنوان انگلیسی The effect of vitamin A supplementation on disease progression, cytokine levels and gene expression in multiple sclerotic patients: study protocol for a randomized controlled trial.
چکیده انگلیسی مقاله Multiple Sclerosis (MS) is a chronic inflammatory disease that leads to degeneration of the brain and spinal tissue. Imbalances of CD4+ T cells including Thelper1 (Th1)/Thelper2 (Th2) and Thelper17 (Th17)/Tregulatory (Treg), their secreted cytokines and gene expressions, are important aspects of in immunopathogenesis of MS. Vitamin A and its metabolites can regulate the immune system and appears to be effective in preventing progression of the autoimmune disease such as MS. Disease progression was evaluated By Magnetic Resonance Imaging (MRI), Expanded Disability States Scale (EDSS) and Multiple Sclerosis Functional Composite (MSFC) tests. Cytokine levels were measured using ELISA kits and gene expression was quantified by Real time PCR (RT-PCR) system. According to the difference between the epidemiological and clinical data on the relationship between vitamin A and immune system regulation, this study of the first time assesses Immune function as well as gene expression and progression of the disease following administration of vitamin A supplement.
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نویسندگان مقاله محمد حسن harrirchian | mohammad hassan harrirchian
iranian center for neurological research, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نیاز محمدزاده هنرور | niyaz mohammadzadeh honarvar
department of cellular and molecular nutrition, faculty of nutritional sciences and dietetics, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

فریبا کوهدانی | fariba koohdani
department of cellular and molecular nutrition, faculty of nutritional sciences and dietetics, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

سما بیطرفان | sama bitarafan
department of cellular and molecular nutrition, faculty of nutritional sciences and dietetics, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

فریدون سیاسی | fereydoon siassi
community nutrition department, faculty of nutritional sciences and dietetics, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

سیما جعفری راد | sima jafarirad
department of cellular and molecular nutrition, faculty of nutritional sciences and dietetics, tehran university of medical sciences, tehran, iran. and department of nutrition, faculty of paramedicine, jundishapur university of medical sciences, ahvaz, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

مینا عبدالهی | mina abdolahi
department of cellular and molecular nutrition, faculty of nutritional sciences and dietetics, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

دکتر عیسی صالحی | eisa salehi
immunology department, faculty of medicine, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

محمد علی saharian | mohammad ali saharian
department of neurology, sina hospital, tehran, iran.


هما rouystaee | homa rouystaee
medicine faculty, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

محمد رضا اشراقیان | mohammad reza eshraghian
department of biostatistics, faculty of public health, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

علی اکبر صبور yarghi | ali akbar saboor yarghi
department of cellular and molecular nutrition, faculty of nutritional sciences and dietetics, tehran university of medical sciences, tehran, iran. and food microbiology research center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/4849
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