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Acta Medica Iranica، جلد ۵۲، شماره ۲، صفحات ۱۰۶-۱۱۰
عنوان فارسی
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عنوان انگلیسی Evaluation of haptoglobin phenotypes in association with clinical features of patients suffered from preterm labor disease.
چکیده انگلیسی مقاله Preterm birth means the birth before thirty seven week of pregnancy that causes a lot of complications for the baby. Variety factors are suggested to be involved in disease. In this study, we decided to evaluate haptoglobin (Hp) phenotypes association with clinical features of patients suffered from premature delivery to understand better the possible correlation of genetic and clinical features in this disease. This cross-sectional analytic descriptive study has been carried out in two groups of 120 women, 60 with preterm and 60 with term labor. Patients were selected with previously diagnosed by gynecologist with preterm birth in the labor during the study period. After performing diagnostic tests, the frequency of each haptoglobin phenotype in the two groups was analyzed using the Chi-square test (X2) test and SPSS software. The maximum serum haptoglobin phenotype frequency in patients with Hp2-2, was 43 (71.7%) whereas in healthy individuals, 35 (58.3%). No, statistically significant differences between the two groups were found (p=0.310). But based on some patients clinical features such as their history of preterm delivery, previous history of recurrent abortions and history of preterm delivery in their family, significant association was found with Hp2-2 compared with healthy control (p< 0.003). This study showed that Hp2-2 phenotypes levels in the case group was higher than in control but the factors influencing the presence or absence of preterm labor is clinically various.
کلیدواژه‌های انگلیسی مقاله Evaluation,Haptoglobin,Phenotypes,Preterm labor
نویسندگان مقاله حسین علی خزایی | hossein ali khazaei
research center for cellular and molecular, zahedan university of medical sciences, zahedan, iran. and department of immunology and hematology, zahedan university of medical sciences, zahedan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زاهدان (Zahedan university of medical sciences)

بتول تیموری | batoul teymuri
department of biochemistry, zahedan university of medical sciences, zahedan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زاهدان (Zahedan university of medical sciences)

علیرضا نخعی | alireza nakhaei
department of gynecology, zahedan university of medical sciences, zahedan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زاهدان (Zahedan university of medical sciences)

مهدی محمدی | mehdi mohammadi
department of biostatistics, zahedan university of medical sciences, zahedan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زاهدان (Zahedan university of medical sciences)

mehrangeez نورا | mehrangeez noura
department of gynecology, zahedan university of medical sciences, zahedan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زاهدان (Zahedan university of medical sciences)

امین خزایی | amin khazaei
research center for cellular and molecular, zahedan university of medical sciences, zahedan, iran. and department of immunology and hematology, zahedan university of medical sciences, zahedan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زاهدان (Zahedan university of medical sciences)

ندا توفیق | neda tofigh
research center for cellular and molecular, zahedan university of medical sciences, zahedan, iran. and department of immunology and hematology, zahedan university of medical sciences, zahedan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زاهدان (Zahedan university of medical sciences)

نیما رضایی | nima rezaei
research center for immunodeficiency, tehran university of medical sciences, tehran, iran. and children amp;amp; 039;s medical center, and molecular immunology research center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/4847
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