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Acta Medica Iranica، جلد ۵۱، شماره ۱۲، صفحات ۸۶۴-۸۷۰
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عنوان انگلیسی Chlamydia pneumoniae in the atherosclerotic plaques of coronary artery disease patients.
چکیده انگلیسی مقاله An association between Chlamydia pneumoniae (C. pneumoniae) and cardiovascular disease has been demonstrated. In this study, we aimed to study this potential relationship in 105 Iranian patients. Coronary artery specimens from 105 Iranian patients undergoing CABG were analyzed by PCR method for C. pneumoniae. Serological evaluation for C. pneumoniae IgG and IgM was performed using ELISA. 53 specimens from mamillary artery were also investigated. C. pneumoniae PCR test result was positive for 23 (21.9%) of patients with coronary artery atherosclerosis, but none of the specimens from the mamillary artery was positive for C. pneumoniae when it was evaluated by the PCR (P< 0.001). Coronary artery disease patients with and without a history of unstable angina or myocardial infarction were comparable in C. pneumoniae PCR test positive rates (P=0.618). Relevance of IgG and IgM positivity were also studied by correlating it to the study parameters, but no difference was found. CRP was significantly higher in the IgM positive group (P< 0.001). A significant proportion of coronary atherosclerotic plaques are infected with C. pneumoniae while no infection was found in the normal mamillary artery specimens. No association was found between acute coronary syndromes and serological and PCR positivity. Further prospective randomized controlled studies with large patient population are needed to confirm our findings.
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نویسندگان مقاله مرتضی ایزدی | morteza izadi
health research center, baqiyatallah university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بقیه الله (Baqiyatallah university of medical sciences)

مژگان فاضل | mozhgan fazel
international travel medicine center of iran, tehran, iran


محسن اکرمی | mohsen akrami
international travel medicine center of iran, tehran, iran.


سید حسن سعادت | seyed hassan saadat
international travel medicine center of iran, tehran, iran.


بهرام پیشگو | bahram pishgoo
international travel medicine center of iran, tehran, iran.


محمد حسن ناصری | mohammad hassan nasseri
international travel medicine center of iran, tehran, iran.


حسین دبیری | hossein dabiri
department of medical microbiology, school of medicine, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

رضا safiaryan | reza safiaryan
health research center, baqiyatallah university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بقیه الله (Baqiyatallah university of medical sciences)

علی اکبر اصفهانی | ali akbar esfahani
health research center, baqiyatallah university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بقیه الله (Baqiyatallah university of medical sciences)

علی احمدی | ali ahmadi
health research center, baqiyatallah university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بقیه الله (Baqiyatallah university of medical sciences)

داود کاظمی صالح | davood kazemi saleh
health research center, baqiyatallah university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بقیه الله (Baqiyatallah university of medical sciences)

محمد حسن کلانتر معتمد | mohammad hassan kalantar motamed
health research center, baqiyatallah university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بقیه الله (Baqiyatallah university of medical sciences)

سعیدطاهری | saeed taheri
dr taheri medical research group, tehran, iran.
نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/4332
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